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Catalog #
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Source:
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Lot #
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Size:
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BP6322b
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In vitro synthesis
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SD050717S
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0.1 mg
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Concentration:
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Accession:
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Synthesis ID:
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Isotype:
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Powder
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NP_001639, P07288
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4032906
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Applications:
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Reactivity:
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MW (kDa):
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2031.8 Da
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Target/Specificity:
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The synthetic peptide sequence used to generate the antibody AP6322b was selected from the C-term region of human KLK3. A 10 to 100 fold molar excess to antibody is recommended. Precise conditions should be optimized for a particular assay.
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Other Names:
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PSA; Kallikrein-3; Semenogelase; Gamma-seminoprotein; Seminin; P-30 antigen;
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Application Data:
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Background:
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Kallikreins are a subgroup of serine proteases having diverse physiological functions. Growing evidence suggests that many kallikreins are implicated in carcinogenesis and some have potential as novel cancer and other disease biomarkers. KLK3 is a protease present in seminal plasma. It is thought to function normally in the liquefaction of seminal coagulum, presumably by hydrolysis of the high molecular mass seminal vesicle protein. Serum level of this protein, called PSA in the clinical setting, is useful in the diagnosis and monitoring of prostatic carcinoma.
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Background References:
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- Binnie, M.C., et al., Prostate 63(4):309-315 (2005).
- Habib, F.K., et al., Int. J. Cancer 114(2):190-194 (2005).
- Laidler, P., et al., Arch. Biochem. Biophys. 435(1):1-14 (2005).
- Dallas, S.L., et al., J. Cell. Physiol. 202(2):361-370 (2005).
- Olsson, A.Y., et al., Genomics 84(1):147-156 (2004).
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Product Citations:
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Application Notes:
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Format:
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The synthetic peptide was lyophilized with 100% acetonitrile and is supplied as a powder. Reconstitute with 0.1 ml deionized water for a final concentration of 1 mg/ml.
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Storage:
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Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C.
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Precautions:
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This product is for research use only. Not for use in diagnostic
or therapeutic procedures.
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