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Anti-Mouse TRIAD3A (N-Terminal) Antibody

Rabbit Anti-Mouse Polyclonal Antibody

  • IHC - Anti-Mouse TRIAD3A (N-Terminal) Antibody  ABD10005
    Formalin fixed, paraffin embedded mouse heart stained with Rabbit anti Mouse TRIAD3A following antigen retrieval using sodium citrate buffer (pH6.0)
  • WB - Anti-Mouse TRIAD3A (N-Terminal) Antibody  ABD10005
    Western blot analysis of mouse heart lysate probed with Rabbit anti Mouse TRIAD3A at 0.5(A), 1(B) and 2(C) ug/ml
Product Information
  • Applications Legend:
  • WB=Western Blot
  • IHC=Immunohistochemistry
  • IHC-P=Immunohistochemistry (Paraffin-embedded Sections)
  • IHC-F=Immunohistochemistry (Frozen Sections)
  • IF=Immunofluorescence
  • FC=Flow Cytopmetry
  • IC=Immunochemistry
  • ICC=Immunocytochemistry
  • IP=Immunoprecipitation
  • DB=Dot Blot
  • CHIP=Chromatin Immunoprecipitation
  • FA=Fluorescence Assay
  • IEM=Immunoelectronmicroscopy
  • EIA=Enzyme Immunoassay
Primary Accession P58283
Reactivity Mouse
Host Rabbit
Clonality Polyclonal
Isotype Polyclonal IgG
Calculated MW 97682 Da
Additional Information
Purification Antisera to mouse TRIAD3A (NT) were raised by repeated immunisations of rabbits with highly purified antigen. Purified IgG prepared by ion exchange chromatography.
Immunogen A 15 amino acid peptide located near mouse TRIAD3A amino-terminus.
Shelf Life 18 months from the date of despatch.
Gene ID 108086
Other Names E3 ubiquitin-protein ligase RNF216, 6.3.2.-, RING finger protein 216, Triad domain-containing protein 3, UbcM4-interacting protein 83, Ubiquitin-conjugating enzyme 7-interacting protein 1, Rnf216, Triad3, Ubce7ip1, Uip83, Zin
Target/Specificity Rabbit anti-Human TRIAD3A antibody recognizes an epitope within the N-terminal region (NT) of mouse TRIAD3A, a ubiquitously expressed E3 ubiquitin-protein ligase which plays an important role in the innate immune response. Regulation of the level and duration of Toll-like receptor (TLR) activation is vital in controlling a pro-inflammatory response, to prevent harm to the host. Several proteins involved in the regulation of TLR signaling have been described including ST2 and IL-1R-associated kinase M, along with many other adaptor proteins of the MyD88 family, which mediate TLR signal transduction. TRIAD3A, identified as a RING finger member of the E3 ligase family of proteins, binds to the cytoplasmic tail of several TLRs, notably TLR4 and TLR9, resulting in ubiquitination and proteolytic degradation, thereby regulating their expression. TRIAD3A does not appear to regulate the expression of TLR2.
Preservative & Stabilisers 0.02% Sodium Azide
Storage Store at +4℃ or at -20 ℃.
PrecautionsAnti-Mouse TRIAD3A (N-Terminal) Antibody is for research use only and not for use in diagnostic or therapeutic procedures.
Research Areas
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1. Chuang, T-H. and Ulevitch, R.J. (2004) Triad3A, an E3 ubiquitin-protein ligase regulating Toll-like receptors.
Nat. Immunol. 5: 495-502.2. Brint, E.K. et al. (2004) ST2 is an inhibitor of interleukin 1 receptor and Toll-like receptor 4 signaling and maintains endotoxin tolerance.
Nature Immunol. 5: 373-379.

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Cat# ABD10005
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