|Application ||WB, IHC-P, FC|
|Other Accession||Q14457, O88597|
|Calculated MW||51557 Da|
|Purification||Antisera to human Beclin-1 (NT) were raised by repeated immunisations of rabbits with highly purified antigen. Purified IgG prepared by affinity chromatography.|
|Immunogen||A 17 amino acid peptide located near human Beclin-1 amino-terminus.|
|Shelf Life||18 months from the date of despatch.|
|Other Names||Beclin-1, Coiled-coil myosin-like BCL2-interacting protein, Protein GT197, Becn1|
|Target/Specificity||Rabbit anti-Human Beclin-1 antibody recognizes an epitope within the N-terminal region of Beclin-1, a ~52 kDa coiled-coil protein which shares structural homology with the yeast autophagy gene apg6/vps30. The ability of cells to undergo bulk degradation of endogenous proteins through an autophagosomic-lysosomal pathway, termed autophagy or Type II cell death, is important in the control of cell growth and development. Studies have identified Beclin-1 as a Bcl-2 interacting mammalian gene which not only mediates autophagy, but also functions as a tumour suppressor, being expressed at reduced levels in human breast carcinoma, and may also play a role in defense against viral infection. An increasing number of studies have revealed an interaction between proteins which induce autophagy and those involved in apoptosis and in some instances apoptosis may be dependant upon or delayed by autophagy.|
|Preservative & Stabilisers||0.02% Sodium Azide (NaN3)|
|Storage||Store at +4℃ or at -20 ℃.|
|Precautions||Anti-Beclin-1 (N-Terminal) Antibody is for research use only and not for use in diagnostic or therapeutic procedures.|
Thousands of laboratories across the world have published research that depended on the performance of antibodies from Abgent to advance their research. Check out links to articles that cite our products in major peer-reviewed journals, organized by research category.
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Provided below are standard protocols that you may find useful for product applications.
1. Liang, X.H. et al. (1999) Induction of autophagy and inhibition of tumorigenesis by beclin 1.Nature. 402: 672-676.2. Gozuacik, D. and Kimchi, A (2004) Autophagy as a cell death and tumor suppressor mechanism.Oncogene. 23: 2891-2906.3. Liang, X.H. et al. (1998) Protection against fatal Sindbis virus encephalitis by Beclin, a novel Bcl-2-interacting protein.J. Virol. 72: 8586-8596.
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