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Anti-Beclin-1 (N-Terminal) Antibody

Rabbit Anti-Human Polyclonal Antibody

  • WB - Anti-Beclin-1 (N-Terminal) Antibody  ABD10008
    Western blot analysis of whole cell lysate from HEK293 human eptihelial kidney cells probed with Rabbit anti Human beclin-1 at 0.5(A), 1(B) and 2(C) ug/ml
  • IHC-P - Anti-Beclin-1 (N-Terminal) Antibody  ABD10008
    Formalin fixed, paraffin embedded rat brain stained with Rabbit anti Human beclin-1 following heat mediated antigen retrieval using sodium citrate buffer (pH6.0)
Product Information
  • Applications Legend:
  • WB=Western Blot
  • IHC=Immunohistochemistry
  • IHC-P=Immunohistochemistry (Paraffin-embedded Sections)
  • IHC-F=Immunohistochemistry (Frozen Sections)
  • IF=Immunofluorescence
  • FC=Flow Cytopmetry
  • IC=Immunochemistry
  • ICC=Immunocytochemistry
  • IP=Immunoprecipitation
  • DB=Dot Blot
  • CHIP=Chromatin Immunoprecipitation
  • FA=Fluorescence Assay
  • IEM=Immunoelectronmicroscopy
  • EIA=Enzyme Immunoassay
Primary Accession Q91XJ1
Other Accession Q14457, O88597
Reactivity Human
Host Rabbit
Clonality Polyclonal
Isotype Polyclonal IgG
Calculated MW 51557 Da
Additional Information
Other Species M,Rat
Purification Antisera to human Beclin-1 (NT) were raised by repeated immunisations of rabbits with highly purified antigen. Purified IgG prepared by affinity chromatography.
Immunogen A 17 amino acid peptide located near human Beclin-1 amino-terminus.
Shelf Life 18 months from the date of despatch.
Gene ID 114558
Other Names Beclin-1, Coiled-coil myosin-like BCL2-interacting protein, Protein GT197, Becn1
Target/Specificity Rabbit anti-Human Beclin-1 antibody recognizes an epitope within the N-terminal region of Beclin-1, a ~52 kDa coiled-coil protein which shares structural homology with the yeast autophagy gene apg6/vps30. The ability of cells to undergo bulk degradation of endogenous proteins through an autophagosomic-lysosomal pathway, termed autophagy or Type II cell death, is important in the control of cell growth and development. Studies have identified Beclin-1 as a Bcl-2 interacting mammalian gene which not only mediates autophagy, but also functions as a tumour suppressor, being expressed at reduced levels in human breast carcinoma, and may also play a role in defense against viral infection. An increasing number of studies have revealed an interaction between proteins which induce autophagy and those involved in apoptosis and in some instances apoptosis may be dependant upon or delayed by autophagy.
Preservative & Stabilisers 0.02% Sodium Azide (NaN3)
Storage Store at +4℃ or at -20 ℃.
PrecautionsAnti-Beclin-1 (N-Terminal) Antibody is for research use only and not for use in diagnostic or therapeutic procedures.
Citations (0)

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1. Liang, X.H. et al. (1999) Induction of autophagy and inhibition of tumorigenesis by beclin 1.
Nature. 402: 672-676.2. Gozuacik, D. and Kimchi, A (2004) Autophagy as a cell death and tumor suppressor mechanism.
Oncogene. 23: 2891-2906.3. Liang, X.H. et al. (1998) Protection against fatal Sindbis virus encephalitis by Beclin, a novel Bcl-2-interacting protein.
J. Virol. 72: 8586-8596.

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Cat# ABD10008
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