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Anti-Human NOD2 (C-Terminal) Antibody

Rabbit Anti-Human Polyclonal Antibody

  • ICC - Anti-Human NOD2 (C-Terminal) Antibody  ABD10010
    Immunocytochemical staining of HeLa cells with Rabbit anti Human NOD2
  • WB - Anti-Human NOD2 (C-Terminal) Antibody  ABD10010
    Western blot analysis of whole cell lysate from HeLa cells probed with Rabbit anti Human NOD2 at 2(A) and 4(B) ug/ml
Product Information
  • Applications Legend:
  • WB=Western Blot
  • IHC=Immunohistochemistry
  • IHC-P=Immunohistochemistry (Paraffin-embedded Sections)
  • IHC-F=Immunohistochemistry (Frozen Sections)
  • IF=Immunofluorescence
  • FC=Flow Cytopmetry
  • IC=Immunochemistry
  • ICC=Immunocytochemistry
  • IP=Immunoprecipitation
  • DB=Dot Blot
  • CHIP=Chromatin Immunoprecipitation
  • FA=Fluorescence Assay
  • IEM=Immunoelectronmicroscopy
  • EIA=Enzyme Immunoassay
Primary Accession Q9HC29
Reactivity Human
Host Rabbit
Clonality Polyclonal
Isotype Polyclonal IgG
Calculated MW 115283 Da
Additional Information
Purification Antisera to NOD2 were raised by repeated immunisations of rabbits with highly purified antigen. Purified IgG prepared by affinity chromatography.
Immunogen 14 amino acids at carboxy terminus of human NOD2.
Shelf Life 18 months from the date of despatch.
Gene ID 64127
Other Names Nucleotide-binding oligomerization domain-containing protein 2, Caspase recruitment domain-containing protein 15, Inflammatory bowel disease protein 1, NOD2, CARD15, IBD1
Target/Specificity Rabbit anti-Human NODs antibody recognizes NOD2, an intracellular protein of ~100 kDa, which belongs to the NOD (nucleotide binding oligomerisation domain) family. The NOD family comprises at present more than 20 different mammalian NOD-LRR (leucine-rich repeat) proteins, which are involved in the regulation of apoptosis and the immune response. NOD2 has been shown to be constitutively or inducibly expressed in monocytes, macrophages, T and B cells, dendritic cells, as well as intestinal epithelial cells. A specific motif of peptidoglycan (PGN), muramyl dipeptide (MDP), has been identified as the sole lNOD2 and Toll-like receptors (TLR) are emerging as key mediators of innate host defence in the intestinal mucosa, crucially involved in maintaining mucosal and commensal homeostasis.Mutations in the gene encoding NOD2 are a major susceptibility factor underlying a significant subgroup of patients with Inflammatory bowel disease 1 (IBD1), a disease characterized by chronic relapsing inflammation of the gastrointestinal tract, subdivided into Crohn disease and ulcerative colitis phenotypes (Hugotet al.2001). Mutations can also lead to development of Blau syndrome (BLAUS) a rare autosomal dominant condition demonstrating early onset granulomatous arthritis, skin rash and uveitis (Parkhouseet al.2014). Additionally mutations in this gene can lead to development of Early onset sarcoidosis (EOS) characterized by the formation of immune granulomas in affected organs, most often the lungs and lymphatics but often other organs can be involved (Okadaet al.2009).
Preservative & Stabilisers 0.02% Sodium Azide (NaN3)
Storage Store at +4℃ or at -20 ℃.
PrecautionsAnti-Human NOD2 (C-Terminal) Antibody is for research use only and not for use in diagnostic or therapeutic procedures.
Research Areas
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1. Inohara, N. & Nuñez, G. (2003) NODs: intracellular proteins involved in inflammation and apoptosis.
Nat Rev Immunol. 3 (5): 371-82.2. Cario, E. (2005) Bacterial interactions with cells of the intestinal mucosa: Toll-like receptors and NOD2.
Gut. 54 (8): 1182-93.3. Girardin, S.E. et al. (2003) Nod2 is a general sensor of peptidoglycan through muramyl dipeptide (MDP) detection.
J Biol Chem. 278 (11): 8869-72.

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Cat# ABD10010
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