|Application ||WB, IHC-F|
|Calculated MW||103829 Da|
|Purification||Antisera to human CD283 were raised by repeated immunisations of rabbits with highly purified antigen. Purified IgG was prepared by ion exchange chromatography.|
|Immunogen||Synthetic peptide corresponding to a 15 amino acid sequence located near human CD283 carboxy-terminus.|
|Shelf Life||18 months from the date of despatch.|
|Other Names||Toll-like receptor 3, CD283, TLR3|
|Target/Specificity||Rabbit anti-Human CD283 antibody recognizes human CD283, otherwise known as toll receptor 3, a 103.8 kDa member of the evolutionarily conserved toll-like receptor family (TLRs), expressed at high levels in the placenta and pancreas and also expressed by dendritic cells.TLRs play an important role in the recognition of invading microbial pathogens during innate immunity, acting through adaptor molecules such as MyD88 and TRAF6. CD283 acts via a cytokine signaling pathway to induce the activation of NF-kappaB and type I interferons, and has been shown to recognize double-stranded viral RNA, including that of the Influenza A and West Nile virus.Rabbit anti-Human CD283 antibody has been shown as suitable for use in IHC on EL4 cytospins at 1ug/ml.|
|Preservative & Stabilisers||0.02% Sodium Azide (NaN3)|
|Storage||Store at +4℃ or at -20 ℃.|
|Precautions||Anti-Human CD283 Antibody is for research use only and not for use in diagnostic or therapeutic procedures.|
Thousands of laboratories across the world have published research that depended on the performance of antibodies from Abgent to advance their research. Check out links to articles that cite our products in major peer-reviewed journals, organized by research category.
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Provided below are standard protocols that you may find useful for product applications.
1. Alexopoulou, L. et al. (2001) Recognition of double-stranded RNA and activation of NF-kappaB by Toll-like receptor 3.Nature. 413 (6857): 732-8.2. Guillot, L. et al. (2005) Involvement of toll-like receptor 3 in the immune response of lung epithelial cells to double-stranded RNA and influenza A virus.J Biol Chem. 280 (7): 5571-80.3. Wang, T. et al. (2004) Toll-like receptor 3 mediates West Nile virus entry into the brain causing lethal encephalitis.Nat Med. 10 (12): 1366-73.
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