|Application ||WB, IHC-F|
|Calculated MW||11557 Da|
|Purification||Antisera to human SUMO-1 were raised by repeated immunisations of rabbits with highly purified antigen. Purified IgG prepared by affinity chromatography.|
|Immunogen||14 amino acid peptide sequence near the amino terminus of human SUMO-1.|
|Shelf Life||18 months from the date of despatch.|
|Other Names||Small ubiquitin-related modifier 1, SUMO-1, GAP-modifying protein 1, GMP1, SMT3 homolog 3, Sentrin, Ubiquitin-homology domain protein PIC1, Ubiquitin-like protein SMT3C, Smt3C, Ubiquitin-like protein UBL1, SUMO1, SMT3C, SMT3H3, UBL1|
|Target/Specificity||ABD10017 detects an epitope within the N-terminal (NT) region of small ubiquitin-related modifier-1 (SUMO-1). SUMO-1 is an 11kD protein which structurally related to ubiquitin, and is added to proteins as a form of post-translational modification known as sumoylation. Sumoylation can be cell cycle regulated, stimulated upon stress or induced by DNA damage, and binding elicits individual effects for each protein. Effects include changes to protein stability, nuclear-cytosolic transport, and transcriptional regulation (mostly transcriptional repression). Alternate transcriptional splice variants encoding different isoforms have been characterized.|
|Preservative & Stabilisers||0.02% Sodium Azide|
|Storage||Store at +4℃ or at -20 ℃.|
|Precautions||Anti-SUMO-1 (N-Terminal) Antibody is for research use only and not for use in diagnostic or therapeutic procedures.|
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