|Application ||WB, IHC-P|
|Calculated MW||27366 Da|
|Purification||Antiserum to p53DINP1 was raised by repeated immunisation of rabbits with highly purified antigen. Purified IgG was prepared from whole serum by immunoaffinity chromatography.|
|Immunogen||A peptide corresponding to 14 amino acids near the amino terminus of human p53DINP1.|
|Shelf Life||18 months from the date of despatch.|
|Other Names||Tumor protein p53-inducible nuclear protein 1, Stress-induced protein, p53-dependent damage-inducible nuclear protein 1, p53DINP1, TP53INP1, P53DINP1, SIP|
|Target/Specificity||Rabbit anti-p53DINP1 antibody recognizes p53DINP1 (p53-dependent damage-inducible nuclear protein 1). The protein promotes p53 phosphorylation on Ser46 in response to DNA double strand breaks, thereby inducing apoptosis. p53DINP1 is found in the nucleus and is ubiquitously expressed. Expression is dramatically reduced in pancreatic ductal adenocarcinomas early in the development of pancreatic cancer.Two isoforms of the protein exists, a 27kDa alpha and an 18kDa beta form. ABD10026 detects a band of 27kDa in human lung tissue lysate. In human spleen, and mouse liver and kidney tissue a band is detected at 18kDa.|
|Preservative & Stabilisers||0.02% Sodium Azide (NaN3)|
|Storage||Store at +4℃ or at -20 ℃.|
|Precautions||Anti-p53DINP1 Antibody is for research use only and not for use in diagnostic or therapeutic procedures.|
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