|Calculated MW||26049 Da|
|Purification||Antiserum to Bcl-xL was raised by repeated immunisation of rabbits with highly purified antigen. Purified IgG was prepared from whole serum by immunoaffinity chromatography.|
|Immunogen||A peptide corresponding to 14 amino acids near the carboxy terminus of human Bcl-xL precursor.|
|Shelf Life||18 months from the date of despatch.|
|Other Names||Bcl-2-like protein 1, Bcl2-L-1, Apoptosis regulator Bcl-X, BCL2L1, BCL2L, BCLX|
|Target/Specificity||Rabbit anti-Human Bcl-xL antibody recognizes the long isoform of human Bcl-2-like protein 1, otherwise known as Bcl-xL, located on the mitochondrial membrane. The Bcl-xL isoform (the longer isoform) is a potent inhibitor of apoptosis. It appears to regulate cell death by binding to and blocking the voltage-dependent anion channel, thereby preventing the release of the caspase activator cytochrome c. High expression of Bcl-xL in tumours correlates to advanced disease and a poor prognosis.|
|Preservative & Stabilisers||0.02% Sodium Azide (NaN3)|
|Storage||Store at +4℃ or at -20 ℃.|
|Precautions||Anti-Human Bcl-xL Antibody is for research use only and not for use in diagnostic or therapeutic procedures.|
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