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>   home   >   Products   >   Primary Antibodies   >   Signal Transduction   >   Anti-Puma Antibody    

Anti-Puma Antibody

Rabbit Anti-Human Polyclonal Antibody

  • IHC - Anti-Puma Antibody  ABD10068
    Staining of human breast carcinoma. Formalin fixed paraffin processed tissue with Rabbit anti Human PUMA (NT) at 10 µg/ml
  • WB - Anti-Puma Antibody  ABD10068
    Western blot analysis of whole cell lysate from K562 cells probed with Rabbit anti Human bcl-2 binding component 3
Product Information
  • Applications Legend:
  • WB=Western Blot
  • IHC=Immunohistochemistry
  • IHC-P=Immunohistochemistry (Paraffin-embedded Sections)
  • IHC-F=Immunohistochemistry (Frozen Sections)
  • IF=Immunofluorescence
  • FC=Flow Cytopmetry
  • IC=Immunochemistry
  • ICC=Immunocytochemistry
  • IP=Immunoprecipitation
  • DB=Dot Blot
  • CHIP=Chromatin Immunoprecipitation
  • FA=Fluorescence Assay
  • IEM=Immunoelectronmicroscopy
  • EIA=Enzyme Immunoassay
Primary Accession Q9BXH1
Reactivity Human
Host Rabbit
Clonality Polyclonal
Isotype Polyclonal IgG
Calculated MW 20532 Da
Additional Information
Purification Antisera to human Bcl-2 binding component 3 were raised by repeated immunisations of rabbits with highly purified antigen. Purified IgG was prepared from whole serum by affinity chromatography.
Immunogen Synthetic peptide ARARQEGSSPEPVEG corresponding to the N-terminus of human Bcl-2 binding component 3.
Shelf Life 18 months from date of despatch.
Gene ID 27113
Other Names Bcl-2-binding component 3, JFY-1, p53 up-regulated modulator of apoptosis, BBC3, PUMA
Target/Specificity Rabbit anti-PUMA antibody recognizes the p53 - upregulated modulator of apoptosis, also known as Bcl-2 binding component 3, JFY-1 or Bcl-2. PUMA is a 193 amino acid ~20 kDa pro-apoptotic member of the BCL-2 family.Bcl-2 binding component 3 is localised to the mitochondria, binds BCL-2 and induces cytochrome C release and apoptosis in response to p53 (Folliset al.2013). Four isoforms of PUMA have been described due to alternative splicing. Rabbit anti-PUMA antibody is expected to recognize the canonical isofom 1, also known as PUMA alpha, it is not expected to recognize any of the other isoforms of PUMA.
Preservative & Stabilisers 0.02% Sodium Azide
Storage Store at +4℃ or at -20 ℃.
PrecautionsAnti-Puma Antibody is for research use only and not for use in diagnostic or therapeutic procedures.
Research Areas
Citations (0)

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1. Naderi, E.H. (2009) Activation of cAMP signaling inhibits DNA damage-induced apoptosis in BCP-ALL cells through abrogation of p53 accumulation.
Blood. 114: 608-18.1. Nakano, K. et al. (2001) PUMA, a novel proapoptotic gene, is induced by p53.
Mol. Cell. 7: 683 - 694.

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Cat# ABD10068
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