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Anti-Human Caspase-1 (C-Terminal) Antibody

Rabbit Anti-Human Polyclonal Antibody

  • WB - Anti-Human Caspase-1 (C-Terminal) Antibody  ABD10077
    Western blot analysis of human heart lysate probed with Rabbit anti Human caspase-1 at 0.5(A), 1(B) and 2(C) ug/ml
  • IHC - Anti-Human Caspase-1 (C-Terminal) Antibody  ABD10077
    Immunohistochemical staining of human heart with Rabbit anti Human caspase-1
Product Information
  • Applications Legend:
  • WB=Western Blot
  • IHC=Immunohistochemistry
  • IHC-P=Immunohistochemistry (Paraffin-embedded Sections)
  • IHC-F=Immunohistochemistry (Frozen Sections)
  • IF=Immunofluorescence
  • FC=Flow Cytopmetry
  • IC=Immunochemistry
  • ICC=Immunocytochemistry
  • IP=Immunoprecipitation
  • DB=Dot Blot
  • CHIP=Chromatin Immunoprecipitation
  • FA=Fluorescence Assay
  • IEM=Immunoelectronmicroscopy
  • EIA=Enzyme Immunoassay
Primary Accession P29466
Reactivity Human
Host Rabbit
Clonality Polyclonal
Isotype Polyclonal IgG
Calculated MW 45159 Da
Additional Information
Purification Purified IgG was prepared by affinity chromatography.
Immunogen A 16 amino acid peptide located near human Caspase-1 carboxy terminus.
Shelf Life 18 months from date of despatch.
Gene ID 834
Other Names Caspase-1, CASP-1,, Interleukin-1 beta convertase, IL-1BC, Interleukin-1 beta-converting enzyme, ICE, IL-1 beta-converting enzyme, p45, Caspase-1 subunit p20, Caspase-1 subunit p10, CASP1, IL1BC, IL1BCE
Target/Specificity Rabbit anti-Human Caspase-1 antibody recognizes an epitope within the C-terminal region (CT) of human Caspase-1, otherwise known as IL-1Beta converting enzyme. Caspase-1 is an intracellular cysteine protease, identified as a mammalian homologue to C. elegans cell death gene (ced-3).Caspase-1 has been classified as an inflammatory, rather than apoptotic caspase, due to its essential role in the cleavage of the inactive precursors of the cytokines IL-1beta and IL-18, into their mature activated and secretable forms. Regulation of pro-inflammatory cytokines by Caspase-1 has made inhibitors of Caspase-1 a possible target for use as therapeutic drugs for the treatment of inflammatory diseases (Ghayuret al.1997).Rabbit anti-Human Caspase-1 antibody detects a cleaved subunit band of approximately 21 kDa in human heart cell lysates (predicted precursor MWT 45.2kDa).
Preservative & Stabilisers 0.02% Sodium Azide
Storage Store at +4℃ or at -20 ℃.
PrecautionsAnti-Human Caspase-1 (C-Terminal) Antibody is for research use only and not for use in diagnostic or therapeutic procedures.
Research Areas
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1. Ghayur, T. et al. (1997) Caspase-1 processes IFN-gamma-inducing factor and regulates LPS-induced IFN-gamma production.
Nature. 386: 619-623.2. Fantuzzi, G. et al. (1998) Interleukin-18 regulation of interferon gamma production and cell proliferation as shown in interleukin-1beta-converting enzyme (caspase-1)-deficient mice.
Blood. 91: 2118-2125.3. Kostura, M.J. et al. (1989) Identification of a monocyte specific pre-interleukin 1beta convertase activity.
P.N.A.S USA 86: 5227-5231.4. Miura, M. et al. (1993) Induction of apoptosis in fibroblasts by IL-1 beta-converting enzyme, a mammalian homolog of the C.elegans cell death gene ced-3.
Cell. 75: 653-660.

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Cat# ABD10077
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