|Application ||WB, IHC-P, E|
|Calculated MW||23315 Da|
|Purification||Purified IgG prepared by affinity chromatography on Protein A from tissue culture supernatant|
|Immunogen||Crude human synaptic immunoprecipitate.|
|Shelf Life||18 months from date of despatch.|
|Other Names||Synaptosomal-associated protein 25, SNAP-25, Super protein, SUP, Synaptosomal-associated 25 kDa protein, SNAP25, SNAP|
|Target/Specificity||Mouse anti-Human SNAP-25 antibody, clone SP12 recognizes the human pre-synaptic protein, SNAP-25, also known as Synaptosomal-associated protein 25, Super protein (SUP) or Synaptosomal-associated 25 kDa protein. SNAP-25 is a 206 amino acid presynaptic protein of ~25kDa containing two t-SNARE coiled-coil homology domains. Mouse anti-human SNAP-25 antibody, clone SP12 will recognize SNAP-25 fusion protein from COS cells, but not the fusion protein from bacterial systems.Mouse anti-Human SNAP-25 antibody, clone SP12 has been used to study the distribution of synaptic changes in the hippocampus of patients with medically refractory temporal lobe epilepsy. (Honeret al.1994).|
|Preservative & Stabilisers||0.09% Sodium Azide|
|Storage||Store at +4℃ or at -20 ℃.|
|Precautions||Anti-Human SNAP-25 Antibody, clone SP12 is for research use only and not for use in diagnostic or therapeutic procedures.|
Thousands of laboratories across the world have published research that depended on the performance of antibodies from Abgent to advance their research. Check out links to articles that cite our products in major peer-reviewed journals, organized by research category.
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Provided below are standard protocols that you may find useful for product applications.
1. Honer, W.G.et al. (1994) Hippocampal synaptic pathology in patients with temporal lobe epilepsy.Acta Neuropathol. 87: 202-210. 2. Honer, W.G et al. (1992) Regional synaptic pathology in Alzheimer's disease.Neurobiol. Aging. 13: 375-382. 3. Honer, W.G. et al. (1993) Human synaptic proteins with a heterogeneous distribution in cerebellum and visual cortex.Brain Res. 609: 9-20. 4. Honer, W.G. et al. (1992) Characterization of a synaptic antigen of interest in neuropsychiatric illness.Biol. Psychiatry 31: 147-158. 5. Honer, W.G.et al. (1989) Monoclonal antibodies to study the brain in schizophrenia.Brain Res. 500: 379-383. 6. Masliah, E. et al. (1994) Topographical distribution of synaptic-associated proteins in the neuritic plaques of Alzheimer's disease hippocampus.Acta Neuropathol. 87: 135-142. 7. Simpson, I.A. et al. (1994) Decreased concentrations of GLUT1 and GLUT3 glucose transporters in the brains of patients with Alzheimer's disease.Ann Neurol. 35: 546-551. 8. Wakabayashi, K. et al. (1994) Synapse alterations in the hippocampalentorhinal formation in Alzheimer's disease with and without Lewy body disease. Brain Res. 667: 24-32. 9. Dickson, D.W. et al. (1994) Hippocampal sclerosis: a common pathological feature of dementia in very old (> or = 80 years of age) humans.Acta Neuropathologica 88: 212-221. 10. Dickson, D.W. et al. (1995) Correlations of synaptic and pathological markers with cognition of the elderly.Neurobiol. Aging 16: 285-98. 11. Bragina, L. et al. (2006) GLT-1 down-regulation induced by clozapine in rat frontal cortex is associated with synaptophysin up-regulation.J Neurochem. 99: 134-41. 12. Steel, G.J. et al. (1997) Evidence for interaction of the fusion protein alpha-SNAP with membrane lipid.Biochem J. 325 : 511-8. 13. Reed, G.L. et al. (1999) Human platelets contain SNARE proteins and a Sec1p homologue that interacts with syntaxin 4 and is phosphorylated after thrombin activation: implications for platelet secretion.Blood. 93: 2617-26. 14. Vannucchi, M.G.
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