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Rat Anti-Mouse Monoclonal Antibody
- SPECIFICATION
- CITATIONS
- PROTOCOLS
- BACKGROUND
Application 
| FC |
|---|---|
| Primary Accession | P25118 |
| Reactivity | Mouse |
| Host | Rat |
| Clonality | Monoclonal |
| Isotype | IgG2a |
| Clone Names | HM104 |
| Calculated MW | 50130 Da |
| Purification | Purified IgG prepared by ion exchange chromatography. |
|---|---|
| Shelf Life | 6 months from date of reconstitution. |
| Gene ID | 21937 |
| Other Names | Tumor necrosis factor receptor superfamily member 1A, Tumor necrosis factor receptor 1, TNF-R1, Tumor necrosis factor receptor type I, TNF-RI, TNFR-I, p55, p60, CD120a, Tnfrsf1a, Tnfr-1, Tnfr1 |
| Target/Specificity | Rat anti-Mouse CD120a antibody, clone HM104 recognizes an extracellular region of mouse CD120a, also known as TNF receptor type I (TNFR1). TNFR1 is an ubiquitously expressed transmembrane glycoprotein and member of the tumor necrosis factor receptor (TNFR) superfamily, which plays a key role in regulating the inflammatory response, acting as a receptor for tumor necrosis factor alpha (TNF-alpha) and lymphotoxin-alpha (TNF-beta). CD120a also plays a role in apoptosis, cytokine induction, cell differentiation, tumor necrosis and early stages of graft-versus-host disease, and its soluble form sTNFR1, acts as an inhibitor of TNF-alpha induced responses by acting as a decoy receptor. |
| Preservative & Stabilisers | 0.09% Sodium azide; Stabilising agent |
| Storage | Storage at +4ºC. DO NOT FREEZE. |
| Precautions | Anti-Mouse CD120a Antibody, clone HM104 (RPE) is for research use only and not for use in diagnostic or therapeutic procedures. |
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Provided below are standard protocols that you may find useful for product applications.
References
1. Pearl-Yafe, M. et al (2010) Tumor Necrosis Factor Receptors Support Murine Hematopoietic Progenitor Function in the Early Stages of Engraftment.Stem Cells. 28: 1270-1280.
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