|Application ||WB, IHC-P|
|Clone Names||F45 P9 C7|
|Calculated MW||50976 Da|
|Purification||Purified IgG prepared by affinity chromatography on Protein G from tissue culture supernatant|
|Immunogen||Ovalbumin-conjugated synthetic peptide SVKQYSGKFF|
|Shelf Life||18 months from date of despatch.|
|Other Names||Heterogeneous nuclear ribonucleoprotein K, hnRNP K, Transformation up-regulated nuclear protein, TUNP, HNRNPK, HNRPK|
|Target/Specificity||Mouse anti-hnRNP K antibody, clone F45 P9 C7 specifically recognizes hnRNP K (heterogeneous ribonucleotide protein K), a 464 amino acid acidic protein found in the nucleus, cytoplasm and mitochondria, shown to be involved in transcription, mRNA shuttling and the translation and editing of RNA.Over-expression of hnRNP K has been demonstrated in cancerous tissue including that of the colon, breast, liver and lungs, and its involvement in cell migration has been implicated in tumour metastasis. Studies have also shown that hnRNP K increases the transcriptional activity of the c-mycandc-srconcogenes.|
|Preservative & Stabilisers||0.09% Sodium Azide|
|Storage||Store at +4℃ or at -20 ℃.|
|Precautions||Anti-hnRNP K Antibody, clone F45 P9 C7 is for research use only and not for use in diagnostic or therapeutic procedures.|
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Provided below are standard protocols that you may find useful for product applications.
1. Carpenter, B. et al. (2006) Heterogeneous nuclear ribonucleoprotein K is over expressed, aberrantly localised and is associated with poor prognosis in colorectal cancer.Br. J. Cancer. 95: 921-927.1. Bomsztyk, K. et al. (1997) Diverse molecular interactions of the hnRNP K protein. FEBS letters 403: 113-115.
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