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>   home   >   Products   >   Primary Antibodies   >   Signal Transduction   >   Anti-Human ANKYRIN-1 Antibody    

Anti-Human ANKYRIN-1 Antibody

Rabbit Anti-Human Polyclonal Antibody

Product Information
  • Applications Legend:
  • WB=Western Blot
  • IHC=Immunohistochemistry
  • IHC-P=Immunohistochemistry (Paraffin-embedded Sections)
  • IHC-F=Immunohistochemistry (Frozen Sections)
  • IF=Immunofluorescence
  • FC=Flow Cytopmetry
  • IC=Immunochemistry
  • ICC=Immunocytochemistry
  • IP=Immunoprecipitation
  • DB=Dot Blot
  • CHIP=Chromatin Immunoprecipitation
  • FA=Fluorescence Assay
  • IEM=Immunoelectronmicroscopy
  • EIA=Enzyme Immunoassay
Primary Accession P16157
Reactivity Human
Host Rabbit
Clonality Polyclonal
Isotype Polyclonal IgG
Calculated MW 206265 Da
Additional Information
Purification Purified IgG prepared by affinity chromatography
Immunogen Synthetic peptide corresponding to the amino acids 1 - 11 of the native protein conjugated to Keyhole Limpet Haemocyanin.
Shelf Life 18 months from date of despatch.
Gene ID 286
Other Names Ankyrin-1, ANK-1, Ankyrin-R, Erythrocyte ankyrin, ANK1, ANK
Target/Specificity Rabbit anti-Human Erythrocyte Ankyrin antibody recognizes erythroid ankyrin (ankyrin-1), also known as ankyrin R or erythrocyte ankyrin. Ankyrin 1 is a 1881 amino acid ~220kDa cytoplasmic protein forming an attachment for a number of integral membrane proteins and cytoskeletal elements. Ankyrin-1 contains a large number of ankyrin repeats, a death domain and two ZU5 domains (UniProt: P16157).Multiple isoforms of ankyrin-1 are generated by alternative splicing and promptor usage, Rabbit anti-Human Erythrocyte Ankyrin antibody is expected to recognize all erythrocyte isoforms of ankyrin-1 but is not expected to recognize the N-terminally truncated muscle isoforms of ankyrin-1. Additionally Rabbit anti-Human Erythrocyte Ankyrin antibody is likely to cross react with ankyrin-1 from chimpanzee (Pan troglodytes) and lowland gorilla (Gorilla gorilla gorilla). Most ankyrins are composed of 3 structural domains; a N-terminal regulatory domain containing multiple ankyrin repeats, a central spectrin binding domain and a C-terminal regulatory domain. Ankyrin-1 is present in erythrocytes and has also been found in brain and muscle. Mutations in erythrocytic ankyrin-1 are associated with hereditary spherocytosis (Eberet al.1996).
Preservative & Stabilisers 0.09% Sodium Azide (NaN3)
Storage Store at +4℃ or at -20 ℃.
PrecautionsAnti-Human ANKYRIN-1 Antibody is for research use only and not for use in diagnostic or therapeutic procedures.
Research Areas
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Cat# ABD10300
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