|Other Accession||P02747, P02745|
|Calculated MW||26722 Da|
|Purification||Antisera to human C1q were raised by repeated immunisation of sheep with highly purified antigen. Purified IgG was prepared from whole serum by protein G affinity chromatography.|
|Shelf Life||18 months from date of despatch.|
|Other Names||Complement C1q subcomponent subunit B, C1QB|
|Target/Specificity||Sheep anti-Human C1q antibody recognizes human C1q, a sub-component of complement C1. C1q associates with complement components C1r and C1s, which are required for the progression of the proteolytic complement cascade. Deficiency of C1q has been associated with lupus erythematosus and glomerulonephritis (Troedsonet al.2013).Sheep anti-human C1q antibody may cross react with C1q in other species.|
|Preservative & Stabilisers||0.01% Thiomersal ; HRP Stabiliser|
|Storage||Store at +4℃. DO NOT FREEZE.|
|Precautions||Anti-Human C1q Antibody (HRP) is for research use only and not for use in diagnostic or therapeutic procedures.|
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Provided below are standard protocols that you may find useful for product applications.
1. Nascimento, E.J. et al. (2009) Alternative complement pathway deregulation is correlated with dengue severity. PLoS One. 4:e6782 2. Lewis, M.J. et al. (2007) The different effector function capabilities of the seven equine IgG subclasses have implications for vaccine strategies.Mol Immunol. 45: 818-27. 3. Jacobs, B.C. et al. (2003) Immunoglobulins inhibit pathophysiological effects of anti-GQ1b-positive sera at motor nerve terminals through inhibition of antibody binding.Brain. 126: 2220-34. 4. Arduin, E. et al. (2015) Highly reduced binding to high and low affinity mouse Fc gamma receptors by L234A/L235A and N297A Fc mutations engineered into mouse IgG2a.Mol Immunol. 63 (2): 456-63. 5. Kao Daniela et al. (2015) A Monosaccharide Residue Is Sufficient to Maintain Mouse and Human IgG Subclass Activity and Directs IgG Effector Functions to Cellular Fc ReceptorsCell Reports. 6 Dec [Epub ahead of print]
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