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>   home   >   Products   >   Primary Antibodies   >   Stem Cells   >   Anti-Glucose Transporter 4 Antibody    

Anti-Glucose Transporter 4 Antibody

Rabbit Anti-Human Polyclonal Antibody

  • IHC - Anti-Glucose Transporter 4 Antibody  ABD10537
    Staining of paraffin embedded human heart, demonstrating labelling of cardiac myocytes
Product Information
  • Applications Legend:
  • WB=Western Blot
  • IHC=Immunohistochemistry
  • IHC-P=Immunohistochemistry (Paraffin-embedded Sections)
  • IHC-F=Immunohistochemistry (Frozen Sections)
  • IF=Immunofluorescence
  • FC=Flow Cytopmetry
  • IC=Immunochemistry
  • ICC=Immunocytochemistry
  • IP=Immunoprecipitation
  • DB=Dot Blot
  • CHIP=Chromatin Immunoprecipitation
  • FA=Fluorescence Assay
  • IEM=Immunoelectronmicroscopy
  • EIA=Enzyme Immunoassay
Primary Accession P14672
Reactivity Human
Host Rabbit
Clonality Polyclonal
Isotype Polyclonal IgG
Calculated MW 54787 Da
Additional Information
Other Species M,Rat,Pr
Purification Purified IgG prepared by affinity chromatography
Immunogen A 12 amino acid peptide corresponding to the carboxyl terminus of the insulin regulatable glucose transporter conjugated to keyhole limpet hemocyanin.
Shelf Life 18 months from date of despatch.
Gene ID 6517
Other Names Solute carrier family 2, facilitated glucose transporter member 4, Glucose transporter type 4, insulin-responsive, GLUT-4, SLC2A4, GLUT4
Target/Specificity Rabbit anti-Glucose Transporter 4 antibody recognizes human Solute carrier family 2, facilitated glucose transporter member 4, also known as glucose transporter 4 or GLUT4. GLUT4 is a 509 amino acid ~50 kDa multi-pass transmembrane protein located primarily in the perinuclear region and is translocated to the plasma membrane where it is rapidly reinternalized. Rabbit anti-Glucose Transporter 4 antibody does not react with HEP G2 type glucose transporter in human erythrocytes, rat brain or other tissues that do not exhibit sensitivity to insulin.GLUT4 is the insulin-regulated glucose transporter found in adipose tissue and striated muscle, responsible for glucose disposal. The stimulation of glucose uptake by insulin requires translocation of the GLUT4 glucose transporter from intracellular storage sites to the cell surface. Activation of phosphatidylinositol-3-OH kinase (PI3K) is required for this trafficking event, but it is not sufficient to produce GLUT4 translocation. Human insulin resistance involves a defect in GLUT4 traffic and targeting leading to accumulation in a dense membrane compartment from which insulin is unable to recruit GLUT4 to the cell surface.
Preservative & Stabilisers 0.09% Sodium Azide
Storage Store at +4℃ or at -20 ℃.
PrecautionsAnti-Glucose Transporter 4 Antibody is for research use only and not for use in diagnostic or therapeutic procedures.
Research Areas
Citations (0)

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1. James, D. E. et al. (1989) Molecular cloning and characterization of an insulin-regulatable glucose transporter.
Nature 338: 83-87. 2. Durante, P.E. et al. (2002) Effects of endurance training on activity and expression of AMP-activated protein kinase isoforms in rat muscles.
Am J Physiol Endocrinol Metab 283: E178-186. 3. Chung, M.J. et al. (2010) Anti-diabetic effects of lemon balm ( Melissa officinalis) essential oil on glucose- and lipid-regulating enzymes in type 2 diabetic mice.
Br J Nutr. 104 (2): 180-8. 4. Ware, B. et al. (2011) Chronic heart failure selectively induces regional heterogeneity of insulin-responsive glucose transporters.
Am J Physiol Regul Integr Comp Physiol. 301: R1300-6. 5. Borghouts, L.B. et al. (2000) GLUT-4 expression is not consistently higher in type-1 than in type-2 fibres of rat and human vastus lateralis muscles; an immunohistochemical study.
Pflugers Arch. 441:351-8. 6. Revheim, M.E. et al. (2013) Intermittent and continuous imatinib in a human GIST xenograft model carrying KIT exon 17 resistance mutation D816H.
Acta Oncol. 52 (4): 776-82. 7. Iwabe, M. et al. (2014) Increased postexercise insulin sensitivity is accompanied by increased AS160 phosphorylation in slow-twitch soleus muscle.
Physiol Rep. 2 (12) pii: e12162.

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Cat# ABD10537
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