|Application ||WB, IHC-F, IP|
|Calculated MW||101579 Da|
|Purification||Purified Ig prepared by affinity chromatography|
|Immunogen||Synthetic peptide corresponding to the C terminal region of the native molecule conjugated to Bovine Serum Albumin.|
|Shelf Life||12 months from date of reconstitution.|
|Other Names||Glutamate receptor 1, GluR-1, AMPA-selective glutamate receptor 1, GluR-A, GluR-K1, Glutamate receptor ionotropic, AMPA 1, GluA1, Gria1, Glur1|
|Target/Specificity||ABD10539 recognises the glutamate receptor 1 (also known as AMPA) which acts as an excitatory neurotransmitter at many synapses in the central nervous system. Binding of the excitatory neurotransmitter L-glutamate induces a conformation change, leading to the opening of the cation channel, and thereby converts the chemical signal to an electrical impulse. The receptor then desensitizes rapidly and enters a transient inactive state, characterized by the presence of bound agonist.This antibody linked to immobilized Protein A immunoprecipitates detergent-solubilized receptor from brain or transfected cells.|
|Preservative & Stabilisers||0.09% Sodium Azide (NaN3)|
|Storage||Store at +4℃ or at -20 ℃.|
|Precautions||Anti-Rat Glutamate Receptor 1 (C-Terminal) Antibody is for research use only and not for use in diagnostic or therapeutic procedures.|
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Provided below are standard protocols that you may find useful for product applications.
1. Petralia, R. S. & Wenthold, R. J. (1992) Light and electron immunocytochemical localization of AMPA-selective glutamate receptors in the rat brainJ Comp Neurol 318: 329 - 354 2. Wenthold, R. J. et al. (1992) Immunochemical characterization of the non-NMDA glutamate receptor using subunit-specific antibodies. Evidence for a hetero-oligomeric structure in rat brainJ Biol Chem 267: 501 - 507
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