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>   home   >   Products   >   Primary Antibodies   >   Signal Transduction   >   Anti-Human Involucrin Antibody, clone SY5    

Anti-Human Involucrin Antibody, clone SY5

Mouse Anti-Human Monoclonal Antibody

Product Information
  • Applications Legend:
  • WB=Western Blot
  • IHC=Immunohistochemistry
  • IHC-P=Immunohistochemistry (Paraffin-embedded Sections)
  • IHC-F=Immunohistochemistry (Frozen Sections)
  • IF=Immunofluorescence
  • FC=Flow Cytopmetry
  • IC=Immunochemistry
  • ICC=Immunocytochemistry
  • IP=Immunoprecipitation
  • DB=Dot Blot
  • CHIP=Chromatin Immunoprecipitation
  • FA=Fluorescence Assay
  • IEM=Immunoelectronmicroscopy
  • EIA=Enzyme Immunoassay
Primary Accession P07476
Reactivity Human
Host Mouse
Clonality Monoclonal
Isotype IgG1
Clone Names SY5
Calculated MW 68479 Da
Additional Information
Other Species Pig,Pr,Dog,Gorilla
Purification Purified IgG prepared by affinity chromatography on Protein A
Immunogen Purified involucrin from human keratinocytes.
Shelf Life 18 months from date of despatch.
Gene ID 3713
Other Names Involucrin, IVL
Target/Specificity Mouse anti-human involucrin antibody, clone SY5 recognizes human involucrin, a 585 amino acid soluble protein encoded by the IVL gene and expressed in epidermal keratinocytes as they tend towards terminal differentiation. involucrin is produced in the stratum spinosum initially in the cell cytosol from where it moves to the cell membrane, associates with transglutaminase and becomes cross-linked to membrane proteins, offering structural support to the cell and forming a stable envelope below the plasma membrane. Mouse anti-human involucrin antibody, clone SY5 recognizes an epitope between residues 421-568 of human involucrin.Involucrin expression is seen in the normal granular cells of the epidermis associated with the plasma membrane during the early phase of cornified envelope maturation (Ishida-Yamamotoet al.1996) and expression is increased in psoriatic epidermis with abnormal cornified envelope maturation (Ishida-Yamamoto and Iizuka 1995). Involucrin staining is also maintained, associated with the cornified envelopein epidermolytic hyperkeratosis, a condition associated with mutations to mutations in genes codong for cytokeratins 1 and 10 (Ishida-Yamamotoet al.1995).
Preservative & Stabilisers 0.09% Sodium Azide (NaN3)
Storage Store at +4℃ or at -20 ℃.
PrecautionsAnti-Human Involucrin Antibody, clone SY5 is for research use only and not for use in diagnostic or therapeutic procedures.
Research Areas
Citations (0)

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1. Hudson, D.L. et al. (1992) Characterization of eight monoclonal antibodies to involucrin.
Hybridoma . 3: 367-79. 2. Ishida-Yamamoto, A. et al. (1997) Involucrin and SPRR Are Synthesized Sequentially in Differentiating Cultured Epidermal Cells.
J Invest Dermatol. 108: 12-6. 3. Caldelari, R. et al. (2000) Long-term culture of murine epidermal keratinocytes.
J Invest Dermatol. 114: 1064-5. 4. Ishida-Yamamoto, A. et al. (1996) Immunoelectron microscopic analysis of cornified cell envelope formation in normal and psoriatic epidermis.
J Histochem Cytochem. 44: 167-75. 5. Janes,S.M. and Watt, F.M. (2004) Switch from alphavbeta5 to alphavbeta6 integrin expression protects squamous cell carcinomas from anoikis.
J Cell Biol. 166: 419-31. 6. Michael, M. et al. (2014) BPAG1-e restricts keratinocyte migration through control of adhesion stability.
J Invest Dermatol. 134: 773-82. 7. Hanada, T. et al. (2014) Keratinization induced by air exposure in the reconstructed human epidermal model: An in vitro model of a cultured epithelial autograft
J Biosci Bioeng. pii: S1389-1723(14)00071-1.

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Cat# ABD10596
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