|Application ||WB, IHC-P, IHC-F|
|Calculated MW||33845 Da|
|Purification||Purified IgG prepared by affinity chromatography on Protein A.|
|Immunogen||Synaptophysin presynaptic vesicles.|
|Shelf Life||18 months from date of despatch.|
|Other Names||Synaptophysin, Major synaptic vesicle protein p38, SYP|
|Target/Specificity||Mouse anti-Human synaptophysin antibody, clone SY38 recognizes synaptophysin, also known as Major synaptic vesicle protein p38. Synaptophysin is a 313 amino acid ~38kDa multi pass transmembrane glycoprotein containing a single MARVEL domain. Synaptophysin is characteristic of small neurosecretory vesicles and is also present in neuroendocrine cells of neuronal and epithelial phenotype (UniProt: P08247). Synaptophysin is widely used as a marker for nerve terminals and for differentiating neuroendocrine tumours.Mouse anti-Human synaptophysin antibody, clone SY38 has been used to detect synaptophysin in a number of neuronal and adrenal tumours including, pheochromocytomas, ganglioneuromas (Paceet al.2002), neuroendocrine tumours of epithelial origin; pancreatic islet cell carcinoma, bronchial and gastrointestinal carcinoids and medullary carcinoma of the thyroid (Wiedenmannet al.1986).|
|Preservative & Stabilisers||0.09% Sodium Azide, 0.5% Bovine Serum Albumin;|
|Storage||Store at +4℃ or at -20 ℃.|
|Precautions||Anti-Synaptophysin Antibody, clone SY38 is for research use only and not for use in diagnostic or therapeutic procedures.|
Thousands of laboratories across the world have published research that depended on the performance of antibodies from Abgent to advance their research. Check out links to articles that cite our products in major peer-reviewed journals, organized by research category.
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Provided below are standard protocols that you may find useful for product applications.
1. Thiele, C. et al. (2000) Cholesterol binds to synaptophysin and is required for biogenesis of synaptic vesicles.Nat Cell Biol. 2: 42-9. 2. Cavalla, P. and Schiffer, D. (2001) Neuroendocrine tumors in the brain.Ann Oncol. 12 Suppl 2:S131-4. 3. Leube, R.E. (1995) The topogenic fate of the polytopic transmembrane proteins, synaptophysin and connexin, is determined by their membrane-spanning domains.J Cell Sci. 108: 883-94. 4. Kahle, P.J. et al. (2000) Subcellular localization of wild-type and Parkinson's disease-associated mutant alpha -synuclein in human and transgenic mouse brain.J Neurosci. 20: 6365-73. 5. González-Jamett, A.M. et al. (2010) The association of dynamin with synaptophysin regulates quantal size and duration of exocytotic events in chromaffin cells.J Neurosci. 30: 10683-91. 6. Kasprzak, A. et al. (2007) Selected markers (chromogranin A, neuron-specific enolase, synaptophysin, protein gene product 9.5) in diagnosis and prognosis of neuroendocrine pulmonary tumours.Pol J Pathol. 58: 23-33. 7. Spiwoks-Becker, I. et al. (2001) Synaptic vesicle alterations in rod photoreceptors of synaptophysin-deficient mice.Neuroscience. 107: 127-42. 8. Zhang, S. et al. (2009) Bronchial Carcinoid Tumor in a Young Man with Neurofibromatosis. Case Report and Review of the LiteratureN A J Med Sci. 2: 17-20. 9. Skripuletz, T. et al. (2013) Astrocytes regulate myelin clearance through recruitment of microglia during cuprizone-induced demyelination.Brain. 136 (Pt 1): 147-67. 10. Grossi, A.B. et al. (2013) Histologic and immunohistochemical classification of 41 bovine adrenal gland neoplasms.Vet Pathol. 50 (3): 534-42.1. Wiedenmann, B. et sal. (1991) Synaptophysin. A widespread constituent of small neuroendocrine vesicles and a new tool in tumor diagnosis.Acta Oncol. 30: 435-40.
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