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>   home   >   Products   >   Primary Antibodies   >   Anti-Dog Thyroid Stimulating Hormone Antibody    

Anti-Dog Thyroid Stimulating Hormone Antibody

Rabbit Anti-Dog Polyclonal Antibody

Product Information
  • Applications Legend:
  • WB=Western Blot
  • IHC=Immunohistochemistry
  • IHC-P=Immunohistochemistry (Paraffin-embedded Sections)
  • IHC-F=Immunohistochemistry (Frozen Sections)
  • IF=Immunofluorescence
  • FC=Flow Cytopmetry
  • IC=Immunochemistry
  • ICC=Immunocytochemistry
  • IP=Immunoprecipitation
  • DB=Dot Blot
  • CHIP=Chromatin Immunoprecipitation
  • FA=Fluorescence Assay
  • IEM=Immunoelectronmicroscopy
  • EIA=Enzyme Immunoassay
Primary Accession P54828
Other Accession Q9XSW8
Reactivity Dog
Host Rabbit
Clonality Polyclonal
Isotype Polyclonal IgG
Calculated MW 15666 Da
Additional Information
Purification Ig fraction prepared by ammonium sulphate precipitation
Immunogen Purified canine TSH.
Shelf Life 12 months from date of reconstitution.
Gene ID 403973
Other Names Thyrotropin subunit beta, Thyroid-stimulating hormone subunit beta, TSH-B, TSH-beta, Thyrotropin beta chain, TSHB
Target/Specificity Rabbit anti-Dog thyroid stimulating hormone polyclonal antibody was raised against highly purified intact canine thyroid stimulating hormone (TSH) and is specific for canine TSH. Rabbit anti-Dog thyroid stimulating hormone exhibits less than 0.1% cross reactivity with the other major canine glycoprotein hormones; growth hormone (GH), luteinizing hormone (LH) and follicle stimulating hormone (FSH) or prolactin using an iodinated hormone tracer assay. This strongly indicates that the anti-thyroid stimulating hormone antibody is primarily reactive with the TSHβ chain although it may also have reactivity with β chain conformational epitopes dependent on the presence of the common α chain shared with the other glycoprotein hormones.TSH, also known as thyrotropin is synthesized in, and secreted from thyrotropes within the anterior pituitary gland, under the influence of secreted thyrotropin releasing hormone from the hypothalamus. TSH is composed of, as are the other major glycoprotein hormones, a common α chain non-covalently linked to a unique β chain responsible for conferring the stuctural and biological identity of the individual hormone. TSH binds to the TSH receptor (TSHR) in the thyroid gland. TSHR has also bee detected in other cell types including adipocytes, neuronal cells and gastric mucosa. Defects in the TSHβ subunit can lead to hypothyroidism, either through the lack of secreted hormone or secretion of TSH lacking full biological acticvity (Szkudlinskiet al.2002).
Preservative & Stabilisers Preservative Free
Storage Prior to reconstitution store at +4℃. Following reconstitution store at -20℃.
PrecautionsAnti-Dog Thyroid Stimulating Hormone Antibody is for research use only and not for use in diagnostic or therapeutic procedures.
Citations (0)

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1. Szkudlinski, M.W. et al. (2002) Thyroid-stimulating hormone and thyroid-stimulating hormone receptor structure-function relationships.
Physiol Rev. 82: 473-502.

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Cat# ABD10793
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