|Application ||WB, IHC-P|
|Calculated MW||115860 Da|
|Purification||Antiserum to mouse CD289 (NT) was raised by repeated immunisation of goats with highly purified antigen. Purified IgG was prepared by affinity chromatography.|
|Immunogen||Synthetic peptide LSLKYNNLTKVPRQLPPSLEY-C corresponding to amino acids 204-224 within the N-terminal region of mouse CD289.|
|Shelf Life||18 months from date of despatch.|
|Other Names||Toll-like receptor 9, CD289, TLR9|
|Target/Specificity||Goat anti-Mouse CD289 antibody recognises murine Toll-like receptor 9, also known as CD289 or TLR9. CD289 is an 1032 amino acid ~120 kDa endosomal single pass type I transmembrane glycoprotein with a number of leucine rich repeats and a single TIR domain (UniProt: Q9NR96). Goat anti-Mouse CD289 antibody recognizes an epitope within the N-terminal (NT) region of CD289, a member of the toll-like receptor family, which triggers MyD88 and TRAF6, resulting in NF-kappaB activation, cytokine secretion and the inflammatory response. CD289 acts as a receptor for unmethylated cytidine-phosphate-guanosine dinucleotides in bacterial DNA (CpG-DNA), playing a primary role in pathogen recognition and activation of innate immunity andhas been shown to play a role in defence against systemic mouse cytomegalovirus infection. Goat anti-Mouse CD289 antibody is reported as suitable for use in immunocytochemistry on acetone fixed cells.|
|Preservative & Stabilisers||0.09% Sodium Azide (NaN3); 0.1% Bovine Serum Albumin;|
|Storage||Store at -20℃ only.|
|Precautions||Anti-Mouse CD289 (N-Terminal) Antibody is for research use only and not for use in diagnostic or therapeutic procedures.|
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1. Ripoll, V.M. et al. (2010) Macrophages from BALB/c and CBA/Ca mice differ in their cellular responses to Streptococcus pneumoniae.J Leukoc Biol. 87: 735-41.
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