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Anti-14-3-3 epsilon (C-Terminal) Antibody (Serum)

Rabbit Anti-Sheep Polyclonal Antibody

  • WB - Anti-14-3-3 epsilon (C-Terminal) Antibody (Serum) ABD10882
    Western blots of 14-3-3 isoforms in HEK293 cell extracts using AbD Serotec antibodies.Lane 1 = anti-gamma 14-3-3 Lane 2 = anti-zeta 14-3-3 Lane 3 = anti-C-epsilon-14-3-3 Lane 4 = anti-N-epsilon-14-3-3 Lane 5 = anti-eta 14-3-3. The 14-3-3 isoforms run at 30 kDa except epsilon 14-3-3 which migrates at 33 kDa
Product Information
  • Applications Legend:
  • WB=Western Blot
  • IHC=Immunohistochemistry
  • IHC-P=Immunohistochemistry (Paraffin-embedded Sections)
  • IHC-F=Immunohistochemistry (Frozen Sections)
  • IF=Immunofluorescence
  • FC=Flow Cytopmetry
  • IC=Immunochemistry
  • ICC=Immunocytochemistry
  • IP=Immunoprecipitation
  • DB=Dot Blot
  • CHIP=Chromatin Immunoprecipitation
  • FA=Fluorescence Assay
  • IEM=Immunoelectronmicroscopy
  • EIA=Enzyme Immunoassay
Primary Accession P62262
Reactivity Sheep
Host Rabbit
Clonality Polyclonal
Isotype Polyclonal IgG
Calculated MW 29174 Da
Additional Information
Other Species M,Rat,Rb,H,B,C
Purification Antisera to sheep anti 14-3-3 epsilon C-terminus were raised by repeated immunisations rabbit of with highly purified antigen.
Immunogen Synthetic corresponding to C-terminal sequence of sheep 14-3-3 epsilon.Peptide sequence: CGEEQNKEALQDVEDENQ
Shelf Life 18 months from date of despatch.
Other Names 14-3-3 protein epsilon, 14-3-3E, Protein kinase C inhibitor protein 1, KCIP-1, YWHAE
Target/Specificity Rabbit anti-14-3-3 antiubody recognizes a C-terminal epitope of 14-3-3 epsilon, a member of the 14-3-3 family which consists of 30 kDa proteins involved in multiple protein kinase signalling pathways, regulation of cell cycle progression, cytoskeletal structure, transcription, intracellular trafficking and targeting. Protein interactions with 14-3-3 show distinct preference for its different isotypes and are regulated by phosphorylation of both 14-3-3 and the bound protein.14-3-3 epsilon is expressed in all mammals. It is deleted in small cell lung cancers disrupting the G checkpoint (Aitken, A. et al.2006). During apoptosis, cleavage of 14-3-3 protein by caspase-3 increases the affinity between bad and Bcl-x(L). When bound by ERK, 14-3-3 epsilon is thought to deactivate heat shock factor 1 in cells recovering from heat shock. It is also a potential suicide susceptibility gene.
Preservative & Stabilisers 0.09% Sodium Azide
Storage Store at +4℃ or at -20 ℃.
PrecautionsAnti-14-3-3 epsilon (C-Terminal) Antibody (Serum) is for research use only and not for use in diagnostic or therapeutic procedures.
Citations (0)

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1. Jones, H. et al. (1995) Expression and Structural Analysis of 14-3-3 Proteins.
J. Mol. Biol. 245: 375-384.1. Aitken, A. et al. (2006) 14-3-3 proteins: A historic overview.
Seminars in Cancer Biology 16: 162-172.

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Cat# ABD10882
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