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>   home   >   Products   >   Primary Antibodies   >   Signal Transduction   >   Anti-LXR alpha/beta Antibody    

Anti-LXR alpha/beta Antibody

Goat Anti-Human Polyclonal Antibody

Product Information
  • Applications Legend:
  • WB=Western Blot
  • IHC=Immunohistochemistry
  • IHC-P=Immunohistochemistry (Paraffin-embedded Sections)
  • IHC-F=Immunohistochemistry (Frozen Sections)
  • IF=Immunofluorescence
  • FC=Flow Cytopmetry
  • IC=Immunochemistry
  • ICC=Immunocytochemistry
  • IP=Immunoprecipitation
  • DB=Dot Blot
  • CHIP=Chromatin Immunoprecipitation
  • FA=Fluorescence Assay
  • IEM=Immunoelectronmicroscopy
  • EIA=Enzyme Immunoassay
Primary Accession Q13133
Other Accession P55055
Reactivity Human
Host Goat
Clonality Polyclonal
Isotype Polyclonal IgG
Calculated MW 50396 Da
Additional Information
Other Species M,Rat
Purification Antisera to human LXR Alpha/Beta were raised by repeated immunisations of goats with highly purified antigen. Purified IgG was prepared from whole serum by affinity chromatography.
Immunogen Peptide sequence CRLQDKKLPPLLSEI corresponding to the internal region of LXR Alpha/Beta (NP_005684; NP_009052).
Shelf Life 18 months from date of despatch.
Gene ID 10062
Other Names Oxysterols receptor LXR-alpha, Liver X receptor alpha, Nuclear receptor subfamily 1 group H member 3, NR1H3, LXRA
Target/Specificity Goat anti-Human LXR alpha/beta antibody recognizes human Oxysterols receptor LXR-alpha, also known as Liver X receptor alpha or Nuclear receptor subfamily 1 group H member 3. Goat anti-Human LXR alpha/beta antibody detects an epitope corresponding to 429-442aa of human LXR (liver X receptor) alpha which has 100% amino acid sequence homology with 443-456aa of human LXR beta. LXR alpha and beta are members of the nuclear hormone receptor superfamily of ligand-activated transcription factors containing a single nuclear receptor DNA binding domain and each have a molecular weight of ~55kDa.LXR alpha and beta are sterol-responsive with the ability to directly bind several oxysterol metabolites. Many LXR target genes have been identified that implicate these receptors in a variety of physiological processes including cholesterol transport and metabolism (Ulvenet al.2005), glucose metabolism, and inflammation (Steffensenet al.2004).
Preservative & Stabilisers 0.02% Sodium Azide; 0.5% Bovine Serum Albumin;
Storage Store at +4℃ or at -20 ℃.
PrecautionsAnti-LXR alpha/beta Antibody is for research use only and not for use in diagnostic or therapeutic procedures.
Research Areas
Citations (0)

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1. Valledor AF. (2005) The innate immune response under the control of the LXR pathway.
Immunobiology. 210: 127-132. 2. Michael, L.F. et al. (2005) The pharmacology of LXR.
Mini Rev Med Chem. 5: 729-740. 3. Ulven SM, et al. (2005) LXR is crucial in lipid metabolism.
Prostaglandins Leukot Essent Fatty Acids. 73: 59-63.

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Cat# ABD10907
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