|Calculated MW||50489 Da|
|Purification||Antisera to RAR beta were raised by repeated immunisations of rabbit with highly purified antigen. Purified IgG prepared by affinity chromatography.|
|Immunogen||Synthetic peptide: C-terminal region of human RAR beta.|
|Shelf Life||18 months from date of despatch.|
|Other Names||Retinoic acid receptor beta, RAR-beta, HBV-activated protein, Nuclear receptor subfamily 1 group B member 2, RAR-epsilon, RARB, HAP, NR1B2|
|Target/Specificity||ABD10920 detects an epitope within the C-terminal (CT) of retinoic acid receptor beta (RAR beta), a 55kD transcriptional factor which is activated by retinoic acid. Once activated RAR beta heterodimerizes with retinoid X receptors (RXRs) and translocates to the nucleus, where it stimulates the transcription of growth-inhibitory, differentiation-inducing genes. In this way RAR beta mediates cellular signalling in embryonic morphogenesis and organogenesis. The RAR beta exists as three isoforms, which are localised to the cytoplasm or subnuclear compartments. Down-regulation of the RAR-b2 isoform occurs early in tumorigenesis, and is a tumour suppressor gene.|
|Preservative & Stabilisers||0.09% Sodium Azide (NaN3)|
|Storage||Store at +4℃ or at -20 ℃.|
|Precautions||Anti-Human RAR beta (C-Terminal) Antibody is for research use only and not for use in diagnostic or therapeutic procedures.|
Thousands of laboratories across the world have published research that depended on the performance of antibodies from Abgent to advance their research. Check out links to articles that cite our products in major peer-reviewed journals, organized by research category.
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Provided below are standard protocols that you may find useful for product applications.
1. Swift, ME. et al. (2006) Truncated RAR beta isoform enhances proliferation and retinoid resistance.J Cell Physiol. 209: 718-725. 2. Desai, T.J. et al. (2006) Distinct roles for retinoic acid receptors alpha and beta in early lung morphogenesis.Dev. Biol. 291: 12-24. 3. Grunt, T.W. et al. (2005) An EGF receptor inhibitor induces RAR-ß expression in breast and ovarian cancer cells.Biochem Biophys Res Commun. 329: 1253-1259.
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