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Anti-Human RAR beta (C-Terminal) Antibody

Rabbit Anti-Human Polyclonal Antibody

  • IHC - Anti-Human RAR beta (C-Terminal) Antibody  ABD10920
    Staining of formalin fixed, paraffin embedded human intermediate trophoblasts with Rabbit anti Human retanoic acid receptor beta
Product Information
  • Applications Legend:
  • WB=Western Blot
  • IHC=Immunohistochemistry
  • IHC-P=Immunohistochemistry (Paraffin-embedded Sections)
  • IHC-F=Immunohistochemistry (Frozen Sections)
  • IF=Immunofluorescence
  • FC=Flow Cytopmetry
  • IC=Immunochemistry
  • ICC=Immunocytochemistry
  • IP=Immunoprecipitation
  • DB=Dot Blot
  • CHIP=Chromatin Immunoprecipitation
  • FA=Fluorescence Assay
  • IEM=Immunoelectronmicroscopy
  • EIA=Enzyme Immunoassay
Primary Accession P10826
Reactivity Human
Host Rabbit
Clonality Polyclonal
Isotype Polyclonal IgG
Calculated MW 50489 Da
Additional Information
Purification Antisera to RAR beta were raised by repeated immunisations of rabbit with highly purified antigen. Purified IgG prepared by affinity chromatography.
Immunogen Synthetic peptide: C-terminal region of human RAR beta.
Shelf Life 18 months from date of despatch.
Gene ID 5915
Other Names Retinoic acid receptor beta, RAR-beta, HBV-activated protein, Nuclear receptor subfamily 1 group B member 2, RAR-epsilon, RARB, HAP, NR1B2
Target/Specificity ABD10920 detects an epitope within the C-terminal (CT) of retinoic acid receptor beta (RAR beta), a 55kD transcriptional factor which is activated by retinoic acid. Once activated RAR beta heterodimerizes with retinoid X receptors (RXRs) and translocates to the nucleus, where it stimulates the transcription of growth-inhibitory, differentiation-inducing genes. In this way RAR beta mediates cellular signalling in embryonic morphogenesis and organogenesis. The RAR beta exists as three isoforms, which are localised to the cytoplasm or subnuclear compartments. Down-regulation of the RAR-b2 isoform occurs early in tumorigenesis, and is a tumour suppressor gene.
Preservative & Stabilisers 0.09% Sodium Azide (NaN3)
Storage Store at +4℃ or at -20 ℃.
PrecautionsAnti-Human RAR beta (C-Terminal) Antibody is for research use only and not for use in diagnostic or therapeutic procedures.
Research Areas
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1. Swift, ME. et al. (2006) Truncated RAR beta isoform enhances proliferation and retinoid resistance.
J Cell Physiol. 209: 718-725. 2. Desai, T.J. et al. (2006) Distinct roles for retinoic acid receptors alpha and beta in early lung morphogenesis.
Dev. Biol. 291: 12-24. 3. Grunt, T.W. et al. (2005) An EGF receptor inhibitor induces RAR-ß expression in breast and ovarian cancer cells.
Biochem Biophys Res Commun. 329: 1253-1259.

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Cat# ABD10920
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