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>   home   >   Products   >   Primary Antibodies   >   Cell Biology   >   Anti-BIK (N-Terminal) Antibody    

Anti-BIK (N-Terminal) Antibody

Rabbit Anti-Human Polyclonal Antibody

  • WB - Anti-BIK (N-Terminal) Antibody  ABD10936
    Western blot analysis of whole cell lysate from Jurkat, human T-cell leukemia cells probed with Rabbit anti Human BIK at 1(A) and 2(B) ug/ml
  • ICC - Anti-BIK (N-Terminal) Antibody  ABD10936
    Imunocytochemical staining of Jurkat cells with Rabbit anti Human BIK
Product Information
  • Applications Legend:
  • WB=Western Blot
  • IHC=Immunohistochemistry
  • IHC-P=Immunohistochemistry (Paraffin-embedded Sections)
  • IHC-F=Immunohistochemistry (Frozen Sections)
  • IF=Immunofluorescence
  • FC=Flow Cytopmetry
  • IC=Immunochemistry
  • ICC=Immunocytochemistry
  • IP=Immunoprecipitation
  • DB=Dot Blot
  • CHIP=Chromatin Immunoprecipitation
  • FA=Fluorescence Assay
  • IEM=Immunoelectronmicroscopy
  • EIA=Enzyme Immunoassay
Primary Accession Q13323
Reactivity Human
Host Rabbit
Clonality Polyclonal
Isotype Polyclonal IgG
Calculated MW 18016 Da
Additional Information
Other Species M
Purification Antisera to Bik were raised by repeated immunisations of rabbits with highly purified antigen. Purified IgG prepared by affinity chromatography.
Immunogen 15 amino acid peptide from near the amino terminus of human Bik.
Shelf Life 18 months from date of despatch.
Gene ID 638
Other Names Bcl-2-interacting killer, Apoptosis inducer NBK, BIP1, BP4, BIK, NBK
Target/Specificity ABD10936 detects an epitope within the N-terminal (NT) region of Bcl-2-interacting killer (Bik) also known as natural born killer (Nbk). Bik is a Bcl-2 homology domain 3 (BH3)-only protein of 18kD which requires the BAX gene for activation. Bik forms heterodimers with various antiapoptotic proteins such as Bcl-2 and Bcl-XL, inhibiting their antiapoptotic function. This can result in the release of Ca2+ and cytochrome C into the cytosol, leading to apoptosis. Loss of Bik is a common feature of clear-cell renal cell carcinoma (RCC), and is thought to act as a renal tissue-specific tumour suppressor gene.
Preservative & Stabilisers 0.02% Sodium Azide
Storage Store at +4℃ or at -20 ℃.
PrecautionsAnti-BIK (N-Terminal) Antibody is for research use only and not for use in diagnostic or therapeutic procedures.
Research Areas
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1. Mathai, J.P. et al. (2005) BH3-only BIK regulates BAX,BAK-dependent release of Ca2+ from endoplasmic reticulum stores and mitochondrial apoptosis during stress-induced cell death.
J. Biol. Chem. 280: 23829-23836.2. Real, P.J. et al. (2006) Transcriptional activation of the proapoptotic bik gene by E2F proteins in cancer cells.
FEBS Lett. 580: 5905-5909.3. Sturm, I. et al. (2006) Loss of the tissue-specific proapoptotic BH3-only protein Nbk/Bik is a unifying feature of renal cell carcinoma.
Cell Death Differ. 13: 619-627.

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Cat# ABD10936
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