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Anti-Human CD281 (N-Terminal) Antibody

Rabbit Anti-Human Polyclonal Antibody

  • IHC - Anti-Human CD281 (N-Terminal) Antibody  ABD10941
    Immunohistochemical staining of mouse spleen with Rabbit anti Human CD281
  • WB - Anti-Human CD281 (N-Terminal) Antibody  ABD10941
    Western blot analysis of mouse spleen lysate probed with Rabbit anti Human CD281 at 1(A), 2(B) and 4(C) ug/ml
Product Information
  • Applications Legend:
  • WB=Western Blot
  • IHC=Immunohistochemistry
  • IHC-P=Immunohistochemistry (Paraffin-embedded Sections)
  • IHC-F=Immunohistochemistry (Frozen Sections)
  • IF=Immunofluorescence
  • FC=Flow Cytopmetry
  • IC=Immunochemistry
  • ICC=Immunocytochemistry
  • IP=Immunoprecipitation
  • DB=Dot Blot
  • CHIP=Chromatin Immunoprecipitation
  • FA=Fluorescence Assay
  • IEM=Immunoelectronmicroscopy
  • EIA=Enzyme Immunoassay
Primary Accession Q15399
Reactivity Human
Host Rabbit
Clonality Polyclonal
Isotype Polyclonal IgG
Calculated MW 90291 Da
Additional Information
Other Species M
Purification Antisera to CD281 were raised by repeated immunisations of rabbits with highly purified antigen. Purified IgG prepared by affinity chromatography.
Immunogen A 16 amino acid peptide located near the amino terminus of human CD281.
Shelf Life 18 months from date of despatch.
Gene ID 7096
Other Names Toll-like receptor 1, Toll/interleukin-1 receptor-like protein, TIL, CD281, TLR1, KIAA0012
Target/Specificity Rabbit anti-Human CD281 antibody detects an epitope within the N-terminal (NT) region of CD281, also known as toll like receptor 1 (TLR1). TLRs recognize pathogen associated molecular patterns (PAMPs) that are expressed on infectious agents, and serve as an important link between the innate and adaptive immune response through the production of cytokines. TLR1 is co-expressed with TLR2 on monocytes and dendritic cells where they form heterodimers that can recognize peptidoglycan and bacterial lipopeptides, and in particular triacylated lipoproteins.TLR1 can also regulate other TLR responses; TLR1 can associate with TLR4 and inhibit its signalling in endothelial cells, and can associate with TLR2 to inhibit the TLR2/TLR6 mediated response to phenol-soluble modulin.
Preservative & Stabilisers 0.02% Sodium Azide (NaN3)
Storage Store at +4℃ or at -20 ℃.
PrecautionsAnti-Human CD281 (N-Terminal) Antibody is for research use only and not for use in diagnostic or therapeutic procedures.
Research Areas
Citations (0)

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1. Hajjar, A.M .et al. (2001) Cutting edge: functional interactions between toll-like receptor (TLR) 2 and TLR1 or TLR6 in response to phenol-soluble modulin.
J Immunol. 166 (1): 15-9.2. Janssens, S. & Beyaert, R. (2003) Role of Toll-like receptors in pathogen recognition.
Clin Microbiol Rev. 16 (4): 637-46.3. Spitzer JH et al. (2002) Toll-like receptor 1 inhibits Toll-like receptor 4 signaling in endothelial cells.
Eur J Immunol. 32 (4): 1182-7.

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Cat# ABD10941
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