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Anti-Human PEN2 (C-Terminal) Antibody

Rabbit Anti-Human Polyclonal Antibody

  • IF - Anti-Human PEN2 (C-Terminal) Antibody  ABD10946
    Immunofluorescence of K562 cells with Rabbit anti PEN2
  • WB - Anti-Human PEN2 (C-Terminal) Antibody  ABD10946
    Western blot analysis of whole cell lysates from K562 human erythromyeloblastoid cells probed with Rabbit anti Human PEN2 AHP1196) at 0.5(A), 1(B) and 2(C) ug/ml
Product Information
  • Applications Legend:
  • WB=Western Blot
  • IHC=Immunohistochemistry
  • IHC-P=Immunohistochemistry (Paraffin-embedded Sections)
  • IHC-F=Immunohistochemistry (Frozen Sections)
  • IF=Immunofluorescence
  • FC=Flow Cytopmetry
  • IC=Immunochemistry
  • ICC=Immunocytochemistry
  • IP=Immunoprecipitation
  • DB=Dot Blot
  • CHIP=Chromatin Immunoprecipitation
  • FA=Fluorescence Assay
  • IEM=Immunoelectronmicroscopy
  • EIA=Enzyme Immunoassay
Primary Accession Q9NZ42
Reactivity Human
Host Rabbit
Clonality Polyclonal
Isotype Polyclonal IgG
Calculated MW 12029 Da
Additional Information
Other Species M,Rat
Purification Antisera to human PEN2 were raised by repeated immunisations of rabbits with highly purified antigen. Purified IgG prepared by affinity chromatography.
Immunogen 13 amino acid peptide sequence near the carboxy terminus of human PEN2.
Shelf Life 18 months from date of despatch.
Gene ID 55851
Other Names Gamma-secretase subunit PEN-2, Presenilin enhancer protein 2, PSENEN, PEN2
Target/Specificity ABD10946 recognises Presenilin enhancer protein 2 (PEN), a 12 kDa member of the PEN2 family and subunit of the gamma-secretase complex. This complex is an endoprotease that cleaves integral membrane proteins. These include Notch receptors and the beta-amyloid precursor protein which is cleaved to form amyloid beta peptide, a major component of the neuritic plaques found in Alzheimer’s disease. The gamma secretase complex consists of nicastrin, the presenilin homodimers and APH1. It is the addition of PEN2, the final stage of gamma secretase maturation that facilitates endoproteolysis of presenilin and confers proteolytic activity. PEN2 expression has been observed in leukocytes, lung, placenta, small intestine, liver, kidney, spleen thymus, skeletal muscle, heart and brain.
Preservative & Stabilisers 0.02% Sodium Azide
Storage Store at +4℃ or at -20 ℃.
PrecautionsAnti-Human PEN2 (C-Terminal) Antibody is for research use only and not for use in diagnostic or therapeutic procedures.
Research Areas
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1. Francis, R. et al. (2002) aph-1 and pen-2 are required for Notch pathway signaling, gamma-secretase cleavage of beta-APP, and presenilin protein accumulation.
Dev. Cell 3:85-97.2. Steiner, H. et al. (2002) PEN-2 is an integral component of the gamma-secretase complex required for coordinated expression of presenilin and nicastrin.
J. Biol. Chem. 277: 39062-39065.

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Cat# ABD10946
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