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>   home   >   Products   >   Primary Antibodies   >   Signal Transduction   >   Anti-Cdk5 (C-Terminal) Antibody (Serum)   

Anti-Cdk5 (C-Terminal) Antibody (Serum)

Rabbit Anti-Human Polyclonal Antibody

Product Information
  • Applications Legend:
  • WB=Western Blot
  • IHC=Immunohistochemistry
  • IHC-P=Immunohistochemistry (Paraffin-embedded Sections)
  • IHC-F=Immunohistochemistry (Frozen Sections)
  • IF=Immunofluorescence
  • FC=Flow Cytopmetry
  • IC=Immunochemistry
  • ICC=Immunocytochemistry
  • IP=Immunoprecipitation
  • DB=Dot Blot
  • CHIP=Chromatin Immunoprecipitation
  • FA=Fluorescence Assay
  • IEM=Immunoelectronmicroscopy
  • EIA=Enzyme Immunoassay
Primary Accession Q00535
Reactivity Human
Host Rabbit
Clonality Polyclonal
Isotype Polyclonal IgG
Calculated MW 33304 Da
Additional Information
Other Species M,Rat
Purification Antisera to Cdk5 were raised by repeated immunisations of rabbits with highly purified antigen.
Immunogen Peptide corresponding to C-terminus of human Cdk5 conjugated to Keyhole Limpet Hemocyanin (KLH).
Shelf Life 18 months from date of despatch.
Gene ID 1020
Other Names Cyclin-dependent-like kinase 5,, Cell division protein kinase 5, Serine/threonine-protein kinase PSSALRE, Tau protein kinase II catalytic subunit, TPKII catalytic subunit, CDK5, CDKN5
Target/Specificity Rabbit anti-Cdk5 antibody detects human cyclin dependent kinase 5 (Cdk5), a proline-directed serine/threonine protein kinase that unlike most Cdks does not function in cell cycle control, and is not regulated by cyclins. Instead, it requires the association p35 or p39 for its kinase activity, resulting in a master regulator of neuronal functions, with roles in neuronal survival and migration, neurotransmitter release and axon guidance.Cdk5 is ubiquitously expressed, but expression and activity is highest in post mitotic neurones, where p35 and p39 are highly expressed. Deregulation of this kinase is neurotoxic and might contribute to the pathogenesis of Alzheimer's disease and other neurodegenerative disorders.
Preservative & Stabilisers 0.01% Sodium Azide (NaN3)
Storage Store at +4℃ or at -20 ℃.
PrecautionsAnti-Cdk5 (C-Terminal) Antibody (Serum) is for research use only and not for use in diagnostic or therapeutic procedures.
Research Areas
Citations (0)

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1. Cheung, Z.H. et al. (2006) Synaptic roles of Cdk5: implications in higher cognitive functions and neurodegenerative diseases.
Neuron. 50 (1): 13-8.2. Pareek, T.K. & Kulkarni, A.B. (2006) Cdk5: a new player in pain signaling.
Cell Cycle. 5 (6): 585-8.3. Cruz, J.C. & Tsai, L.H. (2004) Cdk5 deregulation in the pathogenesis of Alzheimer's disease.
Trends Mol Med. 10 (9): 452-8.

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Cat# ABD10975
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