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Anti-Rat GABA Transporter 3 (C-Terminal) Antibody

Rabbit Anti-Rat Polyclonal Antibody

  • WB - Anti-Rat GABA Transporter 3 (C-Terminal) Antibody  ABD10983
    Western blot of rat hippocampal homogenate showing specific immunolabeling of the ~67 kDa GAT-3 protein.
Product Information
  • Applications Legend:
  • WB=Western Blot
  • IHC=Immunohistochemistry
  • IHC-P=Immunohistochemistry (Paraffin-embedded Sections)
  • IHC-F=Immunohistochemistry (Frozen Sections)
  • IF=Immunofluorescence
  • FC=Flow Cytopmetry
  • IC=Immunochemistry
  • ICC=Immunocytochemistry
  • IP=Immunoprecipitation
  • DB=Dot Blot
  • CHIP=Chromatin Immunoprecipitation
  • FA=Fluorescence Assay
  • IEM=Immunoelectronmicroscopy
  • EIA=Enzyme Immunoassay
Primary Accession P31647
Reactivity Rat
Host Rabbit
Clonality Polyclonal
Isotype Polyclonal IgG
Calculated MW 69947 Da
Additional Information
Purification Antisera to rat GABA transporter 3 (CT) were raised by repeated immunisations of rabbits with highly purified antigen. Purified IgG prepared by affinity chromatography.
Immunogen Synthetic peptide corresponding to the C-terminal region of rat GABA transporter 3.
Shelf Life 12 months from date of reconstitution.
Gene ID 79213
Other Names Sodium- and chloride-dependent GABA transporter 3, GAT-3, Solute carrier family 6 member 11, Slc6a11, Gabt3, Gat-3, Gat-b
Target/Specificity ABD10983 recognises an epitope within the C-terminal region (CT) of rat GABA transporter 3, otherwise known as GAT-3, a 67kDa high-affinity Na+/Cl- dependent plasma membrane transporter and member of the sodium: neurotransmitter symporter (SNF) family, expressed in the cerebral cortex and retina.GAT-3 is one of a group of proteins involved in the regulation of GABAergic synaptic neurotransmission, through the uptake and release of gamma-aminobutyric acid (GABA), the primary inhibitory neurotransmitter of the mammalian central nervous system, which must be maintained at the correct level to ensure successful synaptic transmission. Further GABA transporter genes identified are GAT-1, GAT-2 and GAT-4, and many studies have linked neurotransmitter transporters with neurological disorders, including epilepsy and ischemia.
Preservative & Stabilisers 0.09% Sodium Azide (NaN3); 0.01% Bovine Serum Albumin; 50% Glycerol
Storage Store at +4℃ or at -20 ℃.
PrecautionsAnti-Rat GABA Transporter 3 (C-Terminal) Antibody is for research use only and not for use in diagnostic or therapeutic procedures.
Research Areas
Citations (0)

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1. Conti, F. et al. (2004) GABA transporters in the mammalian cerebral cortex: localization, development and pathological implications.
Brain Res. Rev. 45: 196-212.2. Allen, N.J. et al. (2004) Reversal or reduction of glutamate and GABA transport in CNS pathology and therapy.
Eur. J. Physiol. 449: 132-142.

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Cat# ABD10983
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