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>   home   >   Products   >   Primary Antibodies   >   Anti-Rat Aquaporin 2 (pSer261) Antibody    

Anti-Rat Aquaporin 2 (pSer261) Antibody

Rabbit Anti-Rat Polyclonal Antibody

  • WB - Anti-Rat Aquaporin 2 (pSer261) Antibody  ABD10984
    Western blot of rat kidney lysate showing phosphospecific immunolabeling of the ~29 kDa and ~37 kDa glycosylated form of the AQP2 protein phosphorylated at Ser261
Product Information
  • Applications Legend:
  • WB=Western Blot
  • IHC=Immunohistochemistry
  • IHC-P=Immunohistochemistry (Paraffin-embedded Sections)
  • IHC-F=Immunohistochemistry (Frozen Sections)
  • IF=Immunofluorescence
  • FC=Flow Cytopmetry
  • IC=Immunochemistry
  • ICC=Immunocytochemistry
  • IP=Immunoprecipitation
  • DB=Dot Blot
  • CHIP=Chromatin Immunoprecipitation
  • FA=Fluorescence Assay
  • IEM=Immunoelectronmicroscopy
  • EIA=Enzyme Immunoassay
Primary Accession P34080
Reactivity Rat
Host Rabbit
Clonality Polyclonal
Isotype Polyclonal IgG
Calculated MW 28931 Da
Additional Information
Purification Antisera to rat aquaporin 2 were raised by repeated immunisations of rabbits with highly purified antigen. Purified IgG was prepared by affinity chromatography.
Immunogen Synthetic phosphopeptide corresponding to an amino acid sequence within Aquaporin 2, which includes phosphorylated Ser261.
Shelf Life 12 months from date of reconstitution.
Gene ID 25386
Other Names Aquaporin-2, AQP-2, ADH water channel, Aquaporin-CD, AQP-CD, Collecting duct water channel protein, WCH-CD, Water channel protein for renal collecting duct, Aqp2
Target/Specificity ABD10984 specifically recognises the 29kDa integral membrane protein Aquaporin 2 (AQP2), when phosphorylated at Ser261. AQP2 provides the plasma membranes of the renal collecting duct with a high permeability channel to enable the movement of water across an osmotic gradient, under hormonal regulation by vasopressin. In addition to the Ser256 phosphorylation site, studies have identified a novel phosphorylated Ser261 site on AQP2, which decreases in expression, in response to vasopressin. Gene mutations in AQP2 result in hereditary nephrogenic diabetes insipidus in humans, and acquired diabetes insipidus can also occur through a decrease in the expression of the AQP2 gene, following lithium treatment. Expression of the AQP2 gene is increased during pregnancy and other conditions associated with water retention.
Preservative & Stabilisers 0.09% Sodium Azide (NaN3); 0.01% Bovine Serum Albumin; 50% Glycerol
Storage Store at +4℃ or at -20 ℃.
PrecautionsAnti-Rat Aquaporin 2 (pSer261) Antibody is for research use only and not for use in diagnostic or therapeutic procedures.
Citations (0)

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1. Hoffert, J.D. et al. (2007) Dynamics of aquaporin-2 serine-261 phosphorylation in response to short-term vasopressin treatment in collecting duct.
Am. J. Physiol. Renal Physiol. 292: 691-700.1. Liu, H. and Wintour, E.M. (2005) Aquaporins in development – a review.
Reprod. Biol. Endocrinol. 3: 18-27.

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