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>   home   >   Products   >   Primary Antibodies   >   Anti-Rat Tryptophan Hydroxylase 2 (pSer19) Antibody    

Anti-Rat Tryptophan Hydroxylase 2 (pSer19) Antibody

Rabbit Anti-Rat Polyclonal Antibody

  • WB - Anti-Rat Tryptophan Hydroxylase 2 (pSer19) Antibody  ABD10991
    Western blot of recombinant tryptophan hydroxylase with and without CaMKII showing phosphospecific immunolabeling of ~55 kDa protein phosphorylated at Ser12
Product Information
  • Applications Legend:
  • WB=Western Blot
  • IHC=Immunohistochemistry
  • IHC-P=Immunohistochemistry (Paraffin-embedded Sections)
  • IHC-F=Immunohistochemistry (Frozen Sections)
  • IF=Immunofluorescence
  • FC=Flow Cytopmetry
  • IC=Immunochemistry
  • ICC=Immunocytochemistry
  • IP=Immunoprecipitation
  • DB=Dot Blot
  • CHIP=Chromatin Immunoprecipitation
  • FA=Fluorescence Assay
  • IEM=Immunoelectronmicroscopy
  • EIA=Enzyme Immunoassay
Primary Accession Q8CGU9
Reactivity Rat
Host Rabbit
Clonality Polyclonal
Isotype Polyclonal IgG
Calculated MW 55621 Da
Additional Information
Other Species B,Zf,M,H
Purification Antisera to rat tryptophan hydroxylase 2 were raised by repeated immunisations of rabbits with highly purified antigen. Purified IgG was prepared by affinity chromatography.
Immunogen Synthetic phospeptide corresponding to an amino acid sequence within TPH2, which includes phosphorylated Ser19.
Shelf Life 12 months from date of reconstitution.
Gene ID 317675
Other Names Tryptophan 5-hydroxylase 2,, Neuronal tryptophan hydroxylase, Tryptophan 5-monooxygenase 2, Tph2, Ntph
Target/Specificity ABD10991 specifically recognises the 55kDa Tryptophan Hydroxylase 2 (TPH2) protein, when phosphorylated at Ser19.Tryptophan Hydroxylase (TPH) is a rate-limiting enzyme which catalyses the 5-hydroxylation of tryptophan, to form the amino acid 5-hydroxytryptophan (5-HTP), in the first stage of the biosynthesis of the neurotransmitter serotonin (5-hydroxytryptamine/5HT). Mammalian TPH is encoded by two genes: TPH1 expressed in peripheral tissues e.g. skin and gut, and TPH2 primarily expressed in the brain. Studies have demonstrated the regulation/enhancement of TPH activity through phosphorylation by cAMP-dependent protein kinase (PKA) and Ca2+/calmodulin kinase II (CaMKII), the latter of which phosphorylates a Ser19 site within the regulatory domain of TPH2.
Preservative & Stabilisers 0.09% Sodium Azide (NaN3); 0.01% Bovine Serum Albumin; 50% Glycerol
Storage Store at +4℃ or at -20 ℃.
PrecautionsAnti-Rat Tryptophan Hydroxylase 2 (pSer19) Antibody is for research use only and not for use in diagnostic or therapeutic procedures.
Citations (0)

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1. McKinney, J. et al. (2005) Different properties of the central and peripheral forms of human tryptophan hydroxylase.
J. Neurochem. 92: 311-320

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Cat# ABD10991
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