|Application ||WB, IHC-P|
|Calculated MW||47219 Da|
|Purification||Antiserum to human IRF3 was raised by repeated immunisation of rabbits with highly purified antigen. Purified IgG was prepared from whole serum by affinity chromatography.|
|Immunogen||Synthetic peptide corresponding to a 14 amino acid sequence near the centre of human IRF3.|
|Shelf Life||18 months from date of despatch.|
|Other Names||Interferon regulatory factor 3, IRF-3, IRF3|
|Target/Specificity||ABD11033 recognises Human Interferon Regulatory Factor 3 (IRF3), a member of the interferon regulatory transcription family.IRF3 exists as an inactive cytoplasmic form. dsRNA generated during viral infection leads to the phosphorylation of serine/threonine on the C-terminal. Phosphorylation results in dimerization of IRF3 and association with CREB binding protein. The resulting complex translocates to nucleus and activates the transcription of IFN-alpha and IFN-beta.|
|Preservative & Stabilisers||0.02% Sodium Azide (NaN3)|
|Storage||Store at +4℃ or at -20 ℃.|
|Precautions||Anti-Human IRF3 Antibody is for research use only and not for use in diagnostic or therapeutic procedures.|
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