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Anti-Human PTK7 (N-Terminal) Antibody

Rabbit Anti-Human Polyclonal Antibody

  • IHC - Anti-Human PTK7 (N-Terminal) Antibody  ABD11042
    Formalin fixed, paraffin embedded human colon stained with Rabbit anti Human PTK7 following heat mediated antigen retrieval using sodium citrate buffer (pH6.0)
  • WB - Anti-Human PTK7 (N-Terminal) Antibody  ABD11042
    Western blot analysis of human (A) mouse (B) and Rat (C) colon lysates probed with Rabbit anti Human PTK7 at 1ug/ml
Product Information
  • Applications Legend:
  • WB=Western Blot
  • IHC=Immunohistochemistry
  • IHC-P=Immunohistochemistry (Paraffin-embedded Sections)
  • IHC-F=Immunohistochemistry (Frozen Sections)
  • IF=Immunofluorescence
  • FC=Flow Cytopmetry
  • IC=Immunochemistry
  • ICC=Immunocytochemistry
  • IP=Immunoprecipitation
  • DB=Dot Blot
  • CHIP=Chromatin Immunoprecipitation
  • FA=Fluorescence Assay
  • IEM=Immunoelectronmicroscopy
  • EIA=Enzyme Immunoassay
Primary Accession Q13308
Reactivity Human
Host Rabbit
Clonality Polyclonal
Isotype Polyclonal IgG
Calculated MW 118392 Da
Additional Information
Other Species Rat,M
Purification Purified IgG was prepared by affinity chromatography.
Immunogen A 15 amino acid peptide located near the N-terminal region of human PTK7.
Shelf Life 18 months from date of despatch.
Gene ID 5754
Other Names Inactive tyrosine-protein kinase 7, Colon carcinoma kinase 4, CCK-4, Protein-tyrosine kinase 7, Pseudo tyrosine kinase receptor 7, Tyrosine-protein kinase-like 7, PTK7, CCK4
Target/Specificity ABD11042 recognises human Protein tyrosine kinase-like 7 (PTK7), a member of the receptor tyrosine kinase family, otherwise known as Colon Carcinoma Kinase 4 (CCK4). PTK7 is highly expressed in the kidney, liver, lung, pancreas and melanocytes with weaker expression being detected in the thyroid gland, ovaries, brain, heart and skeletal muscle. PTK7 may play a role in embryonic development. It is thought to function as a cell adhesion molecule and as a novel regulator of the planar cell polarity (PCP) pathway in vertebrates. Studies also suggest that PTK7 may be involved in the tumour progression. A loss of PTK7 expression has been observed in melanoma cell lines, whereas increased levels of PTK7 have been detected in high-throughput acute myeloid leukaemia samples. In addition, PTK7 is not expressed in normal colon but has been detected in colon carcinomas and as such is a potential marker for tumour progression.
Preservative & Stabilisers 0.02% Sodium Azide
Storage Store at +4℃ or at -20 ℃.
PrecautionsAnti-Human PTK7 (N-Terminal) Antibody is for research use only and not for use in diagnostic or therapeutic procedures.
Research Areas
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1. Lu, X. et al. (2004) PTK7/CCK-4 is a novel regulator of planar cell polarity in vertebrates.
Nature.430:93 – 982. Easty, D.J. et al. (1997) Loss of expression of receptor tyrosine kinase family genes PTK7 and SEK in metastatic melanoma.
Int J Cancer.71:1061 - 1065

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Cat# ABD11042
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