|Application ||WB, IHC-F|
|Calculated MW||93611 Da|
|Purification||Purified IgG was prepared by affinity chromatography.|
|Immunogen||An 18 amino acid peptide located near the centre of human DISC1.|
|Shelf Life||18 months from date of despatch.|
|Other Names||Disrupted in schizophrenia 1 protein, DISC1, KIAA0457|
|Target/Specificity||Rabbit anti-DISC1 antibody recognizes disrupted in schizophrenia 1 (DISC1), ~93 kDa protein located in the nucleus, cytoplasm and mitochondria. The DISC1 protein is widely expressed in normal tissues. It is involved in neurite outgrowth and cortical development through its interaction with a variety of proteins including lissencephaly-1 (LIS1), NudeE-like (NUDEL) and phosphodiesterase 4B. In certain cases of schizophrenia the DISC1 gene has been found to be disrupted by a t(1;11) (q42.1;q14.3) translocation, and studies suggest that DISC1 could be a candidate susceptibility gene for this condition.Rabbit anti-DISC1 antibody has been found suitable for immunocytochemistry (ICC) at a concentration of 5ug/ml.|
|Preservative & Stabilisers||0.02% Sodium Azide|
|Storage||Store at +4℃ or at -20 ℃.|
|Precautions||Anti-DISC1 Antibody is for research use only and not for use in diagnostic or therapeutic procedures.|
Thousands of laboratories across the world have published research that depended on the performance of antibodies from Abgent to advance their research. Check out links to articles that cite our products in major peer-reviewed journals, organized by research category.
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Provided below are standard protocols that you may find useful for product applications.
1. Mühlhans J et al. (2011) The centrosomal protein pericentrin identified at the basal body complex of the connecting cilium in mouse photoreceptors.PLoS One. 6 (10): e26496.1. Taya, S. et al. (2007) DISC1 regulates the transport of the NUDEL/LIS1/14-3-3eta complex through kinesin-1. J Neurosci.27:15 - 26
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