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Anti-DISC1 Antibody

Rabbit Anti-Human Polyclonal Antibody

  • ICC - Anti-DISC1 Antibody  ABD11043
    Immunocytochemical staining of HeLa cells with Rabbit anti Human DISC1
  • WB - Anti-DISC1 Antibody  ABD11043
    Western blot analysis of whole cell lysate from SK-N-SH human neuroblastoma cells probed with Rabbit anti Human DISC1 at 0.5(A), 1(B) and 2(C) ug/ml
  • IF - Anti-DISC1 Antibody  ABD11043
    Published customer image:Rabbit anti DISC1 antibody used forthe detection of DISC1 in mouse photoreceptors by immunofluorescence.Image caption:Colocalization of various Pericentrin interaction partners at the basal body complex of mouse photoreceptors. (A) Scheme of a vertebrate rod photoreceptor. (B–F) Micrographs of a vertical cryostat section through an adult mouse retina double labeled for CG-NAP (B, green) and Cen3 (C, red) as a marker for the ciliary apparatus (the connecting cilium and the basal body complex ) and the centrosomes. (B) CG-NAP and (C) Cen3 are localized in the ciliary region of the photoreceptors and at the centrosomes of the other retinal cells. (D) The merge of the stainings with the additional DAPI nuclear staining shows the partial colocalization of CG-NAP and Cen3 in the ciliary region of the photoreceptors and the centrosomes of the other retinal cells. (E–F) High power views showing the localization of CG-NAP at the BBC of the connecting cilium (E) and at the centrosomes of the other retinal cells (F). (G) Scheme of the ciliary apparatus. (H–K) High power views showing the localization of the Pcnt interaction partners PCM1 (H, green), DISC1 (I, green), IFT20 (J, green), and PC2 (K, green) at the BBC of the connecting cilium of the photoreceptor. Cen3 marks the whole cilium with the ciliary apparatus. RPE: retinal pigment epithel; OS: outer segment; IS: inner segment; ONL: outer nuclear layer; OPL: outer plexiform layer; BB: basal body; CC: connecting cilium; C: centriole; CP: calycal process; MTs: microtubules; N: nucleus; S: synapse. Scale bars: 10 µm (B), 1 µm (E, F, J, K, H, I).From: Mühlhans J, Brandstätter JH, Gießl A The Centrosomal Protein Pericentrin Identified at the Basal Body Complex of the Connecting Cilium in Mouse Photoreceptors.PLoS ONE 6: e26496. doi:10.1371/journal.pone.0026496
Product Information
  • Applications Legend:
  • WB=Western Blot
  • IHC=Immunohistochemistry
  • IHC-P=Immunohistochemistry (Paraffin-embedded Sections)
  • IHC-F=Immunohistochemistry (Frozen Sections)
  • IF=Immunofluorescence
  • FC=Flow Cytopmetry
  • IC=Immunochemistry
  • ICC=Immunocytochemistry
  • IP=Immunoprecipitation
  • DB=Dot Blot
  • CHIP=Chromatin Immunoprecipitation
  • FA=Fluorescence Assay
  • IEM=Immunoelectronmicroscopy
  • EIA=Enzyme Immunoassay
Primary Accession Q9NRI5
Reactivity Human
Host Rabbit
Clonality Polyclonal
Isotype Polyclonal IgG
Calculated MW 93611 Da
Additional Information
Other Species M
Purification Purified IgG was prepared by affinity chromatography.
Immunogen An 18 amino acid peptide located near the centre of human DISC1.
Shelf Life 18 months from date of despatch.
Gene ID 27185
Other Names Disrupted in schizophrenia 1 protein, DISC1, KIAA0457
Target/Specificity Rabbit anti-DISC1 antibody recognizes disrupted in schizophrenia 1 (DISC1), ~93 kDa protein located in the nucleus, cytoplasm and mitochondria. The DISC1 protein is widely expressed in normal tissues. It is involved in neurite outgrowth and cortical development through its interaction with a variety of proteins including lissencephaly-1 (LIS1), NudeE-like (NUDEL) and phosphodiesterase 4B. In certain cases of schizophrenia the DISC1 gene has been found to be disrupted by a t(1;11) (q42.1;q14.3) translocation, and studies suggest that DISC1 could be a candidate susceptibility gene for this condition.Rabbit anti-DISC1 antibody has been found suitable for immunocytochemistry (ICC) at a concentration of 5ug/ml.
Preservative & Stabilisers 0.02% Sodium Azide
Storage Store at +4℃ or at -20 ℃.
PrecautionsAnti-DISC1 Antibody is for research use only and not for use in diagnostic or therapeutic procedures.
Research Areas
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1. Mühlhans J et al. (2011) The centrosomal protein pericentrin identified at the basal body complex of the connecting cilium in mouse photoreceptors.
PLoS One. 6 (10): e26496.1. Taya, S. et al. (2007) DISC1 regulates the transport of the NUDEL/LIS1/14-3-3eta complex through kinesin-1.
J Neurosci.27:15 - 26

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Cat# ABD11043
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