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>   home   >   Products   >   Primary Antibodies   >   Signal Transduction   >   Anti-5-Lipoxygenase (pSer523) Antibody    

Anti-5-Lipoxygenase (pSer523) Antibody

Rabbit Anti-Human Polyclonal Antibody

  • WB - Anti-5-Lipoxygenase (pSer523) Antibody  ABD11070
    Western blot of rat hippocampal lysate showing phospho-specific immunolabelling of the ~80 kDa doublet of 5-LO phosphorylated at Ser523
Product Information
  • Applications Legend:
  • WB=Western Blot
  • IHC=Immunohistochemistry
  • IHC-P=Immunohistochemistry (Paraffin-embedded Sections)
  • IHC-F=Immunohistochemistry (Frozen Sections)
  • IF=Immunofluorescence
  • FC=Flow Cytopmetry
  • IC=Immunochemistry
  • ICC=Immunocytochemistry
  • IP=Immunoprecipitation
  • DB=Dot Blot
  • CHIP=Chromatin Immunoprecipitation
  • FA=Fluorescence Assay
  • IEM=Immunoelectronmicroscopy
  • EIA=Enzyme Immunoassay
Primary Accession P09917
Reactivity Human
Host Rabbit
Clonality Polyclonal
Isotype Polyclonal IgG
Calculated MW 77983 Da
Additional Information
Other Species Primate,Rat
Purification Antisera to phosphorylated 5-lipoxygenase were raised by repeated immunisations of rabbits with highly purified antigen. Purified IgG prepared by affinity chromatography.
Immunogen Synthetic phosphopeptide corresponding to an amino acid sequence within human 5-lipoxygenase which includes phosphorylated Ser523.
Shelf Life 18 months from date of despatch.
Gene ID 240
Other Names Arachidonate 5-lipoxygenase, 5-LO, 5-lipoxygenase,, ALOX5, LOG5
Target/Specificity ABD11070 specifically recognises human 5-lipoxygenase (5-LO, also known as arachidonate 5-lipoxygenase) when phosphorylated at Ser523. 5-LO is an enzyme that catalyses the synthesis of leukotrienes (LT’s) from arachidonic acid (a polyunsaturated fatty acid), by the insertion of an oxygen into the arachidonic backbone. 5-LO requires calcium, ATP and the 5-LO-activating protein as cofactors for full activity. Leukotrienes are synthesised and secreted by leukocytes in response to immunologic or inflammatory stimuli, such as in asthma and allergic reactions. The biological effects of LT’s include leukocyte chemotaxis, pulmonary airway constriction, mucous hypersecretion, vasoconstriction and increased vascular permeability. I recent years 5-LO has also been implicated in the regulation of cell proliferation and apoptosis and has been found in a broad variety of cancer cells.
Preservative & Stabilisers 0.09% Sodium Azide; 0.01% Bovine Serum Albumin; 50% Glycerol
Storage Store at +4℃ or at -20 ℃.
PrecautionsAnti-5-Lipoxygenase (pSer523) Antibody is for research use only and not for use in diagnostic or therapeutic procedures.
Research Areas
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Cat# ABD11070
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