|Application ||WB, E|
|Calculated MW||23668 Da|
|Purification||Antiserum to human RAB8A (CT) was raised by repeated immunisation of goats with highly purified antigen. Purified IgG was prepared by affinity chromatography.|
|Immunogen||Peptide sequence C-NQGVKITPDQQKR from the C-Terminal region of RAB8A (NP_005361.2).|
|Shelf Life||18 months from date of despatch.|
|Other Names||Ras-related protein Rab-8A, Oncogene c-mel, RAB8A, MEL, RAB8|
|Target/Specificity||Goat anti-Human RAB8A antibody recognizes an epitope within the C-terminal (CT) region of the human RAS superfamily member Rab8a (Ras-related protein Rab-8A), otherwise known as oncogene c-mel, Rab8A is a small monomeric GTP/GDP-binding protein with a predicted molecular weight of ~24kDa which may play a role in vesicular trafficking and neurotransmitter release.The Rab family of proteins, originally described as Ras-like proteins in brain are the largest group of GTPases within the Ras superfamily with 61 protein members identified. Rab family members are involved in the regulation of intracellular vesicular transport and movement of proteins between endocytic and secretory organelles (Wennerberget al.2005). Rab8A is involved in vesicular traffic between the trans golgi network and the basoleteral aspect of the plasma membrane (Huberet al.1993). Goat anti-human Rab8a antibody has been successfully used for the detection of Rab8a in human intestinal epithelial cells using Western blotting (Vaccaet al.2014).|
|Preservative & Stabilisers||0.02% Sodium Azide (NaN3); 0.5% Bovine Serum Albumin;|
|Storage||Store at +4℃ or at -20 ℃.|
|Precautions||Anti-Human RAB8A (C-Terminal) Antibody is for research use only and not for use in diagnostic or therapeutic procedures.|
Thousands of laboratories across the world have published research that depended on the performance of antibodies from Abgent to advance their research. Check out links to articles that cite our products in major peer-reviewed journals, organized by research category.
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Provided below are standard protocols that you may find useful for product applications.
1. Vacca, B. et al. (2014) Drebrin E depletion in human intestinal epithelial cells mimics Rab8a loss of function.Hum Mol Genet. 23 (11): 2834-46.
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