|Application ||WB, IHC-P, E|
|Calculated MW||44341 Da|
|Purification||Antisera to Human TGF-beta1 were raised by repeated immunisation of Rabbits with highly purified antigen. Purified IgG prepared from whole serum by affinity chromatography.|
|Immunogen||A synthetic peptide corresponding to amino acids 286-293 of the human TGF-beta precursor protein.|
|Shelf Life||18 months from date of despatch.|
|Other Names||Transforming growth factor beta-1, TGF-beta-1, Latency-associated peptide, LAP, TGFB1, TGFB|
|Target/Specificity||Rabbit anti-Human TGF beta antibody recognizes human Transforming Growth Factor Beta 1 (TGF-beta1), a 390 amino acid secreted protein belonging to the TGF-beta family.TGF-beta1 is a multifunctional protein that controls proliferation, differentiation and other functions in a wide range of cell types and both positively and negatively regulates many other growth factors. TGF-beta1 also plays an important role in bone remodelling through stimulation of oesteoblastic bone formation causing chemotaxis, proliferation and differentiation in committed osteoblasts. Defects in TGFB1 are the cause of Camurati-Engelmann disease (CED), also known as progressive diaphyseal dysplasia 1 (Kinoshitaet al.2000).|
|Preservative & Stabilisers||0.09% Sodium Azide (NaN3)|
|Storage||Store at +4℃ or at -20 ℃.|
|Precautions||Anti-Human TGF beta Antibody is for research use only and not for use in diagnostic or therapeutic procedures.|
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Provided below are standard protocols that you may find useful for product applications.
1. Polichnowski, A.J. et al. (2014) Severe Renal Mass Reduction Impairs Recovery and Promotes Fibrosis after AKI.J Am Soc Nephrol. 25: 1496-1507. 2. Moore, L.B. et al. (2015) Loss of monocyte chemoattractant protein-1 alters macrophage polarization and reduces NFκB activation in the foreign body response.Acta Biomater. 11: 37-47. 3. Geng, H. et al. (2012) Lysophosphatidic acid increases proximal tubule cell secretion of profibrotic cytokines PDGF-B and CTGF through LPA2- and Gαq-mediated Rho and αvβ6 integrin-dependent activation of TGF-β.Am J Pathol. 181: 1236-49. 4. Tark, K.C. et al. (2015) Effects of ginsenoside Rb1 on hypertrophic scar remodeling in rabbit model.Eur J Pharmacol. 750C: 151-59.
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