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Anti-Human NALP3 (C-Terminal) Antibody

Goat Anti-Human Polyclonal Antibody

  • IHC - Anti-Human NALP3 (C-Terminal) Antibody  ABD11142
    Staining of formalin fixed human peripheral blood leukocytes with Goat annti Human NALP3
Product Information
  • Applications Legend:
  • WB=Western Blot
  • IHC=Immunohistochemistry
  • IHC-P=Immunohistochemistry (Paraffin-embedded Sections)
  • IHC-F=Immunohistochemistry (Frozen Sections)
  • IF=Immunofluorescence
  • FC=Flow Cytopmetry
  • IC=Immunochemistry
  • ICC=Immunocytochemistry
  • IP=Immunoprecipitation
  • DB=Dot Blot
  • CHIP=Chromatin Immunoprecipitation
  • FA=Fluorescence Assay
  • IEM=Immunoelectronmicroscopy
  • EIA=Enzyme Immunoassay
Primary Accession Q96P20
Reactivity Human
Host Goat
Clonality Polyclonal
Isotype Polyclonal IgG
Calculated MW 118173 Da
Additional Information
Other Species Rat
Purification Antisera to human NALP3 were raised by repeated immunisation of goats with highly purified antigen. Purified IgG prepared from whole serum by affinity chromatography.
Immunogen Synthetic peptide sequence corresponding to C-EKPELTVVFEPSW from the C Terminus of Human NALP3 (NP_004886).
Shelf Life 18 months from date of despatch.
Gene ID 114548
Other Names NACHT, LRR and PYD domains-containing protein 3, Angiotensin/vasopressin receptor AII/AVP-like, Caterpiller protein 1.1, CLR1.1, Cold autoinflammatory syndrome 1 protein, Cryopyrin, PYRIN-containing APAF1-like protein 1, NLRP3, C1orf7, CIAS1, NALP3, PYPAF1
Target/Specificity Goat anti-Human NALP3 antibody recognizes human NACHT, LRR and PYD domains-containing protein 3 (NALP3), also known as Angiotensin/vasopressin receptor AII/AVP-like, Caterpiller protein 1.1 or Cryopyrin. NALP3 is a 1036 amino acid ~120kDa cytoplasmic protein belonging to the NLRP family, containing a single DAPIN domain, nine leucine-rich repeats and a single NACHT domain (UniProt: Q96P20) .NALP3 is involved in inflammation and immune responses. NALP3 may function as an activator of NF-kappaB signalling and play a role in the regulation of inflammation and apoptosis (Choi and Ryter 2014). NALP3 is strongly expressed in polymorphonuclear cells, osteoblasts and chondrocytes, NALP3 can also be detected in non-keratinizing epithelia of oropharynx, esophagus and ectocervix and in the urothelial layer of the bladder.Mutations in the NALP3 gene have been associated with familial cold autoinflammatory syndrome (Hoffmanet al.2001), Muckle-Wells syndrome (Dodéet al.2002), chronic infantile neurological cutaneous and articular syndrome (Feldmannet al.2002) and neonatal-onset multisystem inflammatory disease (Aksentijevichet al.2002).Goat anti-Human NALP3 antibody has been used successfuly for the detection of NALP3 in the eyes of rats by immunohistochemistry on formalin fixed, paraffin embedded sections (Liuet al.2014).
Preservative & Stabilisers 0.02% Sodium Azide (NaN3); 0.5% Bovine Serum Albumin;
Storage Store at +4℃ or at -20 ℃.
PrecautionsAnti-Human NALP3 (C-Terminal) Antibody is for research use only and not for use in diagnostic or therapeutic procedures.
Research Areas
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1. Liu, R.T. et al. (2014) Vinpocetine inhibits amyloid-beta induced activation of NF-?B, NLRP3 inflammasome and cytokine production in retinal pigment epithelial cells.
Exp Eye Res. pii: S0014-4835(14)00185-7.

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Cat# ABD11142
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