|Application ||WB, E|
|Calculated MW||79919 Da|
|Purification||Antiserum to human FOXP2 (CT) was raised by repeated immunisation of goats with highly purified antigen. Purified IgG was prepared by affinity chromatography.|
|Immunogen||Peptide with sequence C-REIEEEPLSEDLE from the C Terminus of FOXP2.|
|Shelf Life||18 months from date of despatch.|
|Other Names||Forkhead box protein P2, CAG repeat protein 44, Trinucleotide repeat-containing gene 10 protein, FOXP2, CAGH44, TNRC10|
|Target/Specificity||Goat anti-Human FOXP2 antibody recognizes Forkhead box protein P2, also known as FOXP2, CAG repeat protein 44 or Trinucleotide repeat-containing gene 10 protein. FOXP2 is a 715 amino acid ~80 kDa nuclear transcriptional repressor with a role in brain and lung development.Mutations in the FOXP2 gene has been identified Speech-language disorder 1 (SPCH1), a disorder characterized by severe orofacial dyspraxia with speech impairment (Laiet al.2001).Multiple potential isoforms of FOXP2 generated by alternative splicing have been described. Goat anti-Human FOXP2 antibody (ABD11197) is expected to recognize the canonical isoform 1 and also isoforms 3 and 9. However the antibody is not expected other isoforms which lack the c-terminal region (UniProt : 015409).|
|Preservative & Stabilisers||0.02% Sodium Azide (NaN3); 0.5% Bovine Serum Albumin;|
|Storage||Store at +4℃ or at -20 ℃.|
|Precautions||Anti-Human FOXP2 (C-Terminal) Antibody is for research use only and not for use in diagnostic or therapeutic procedures.|
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Provided below are standard protocols that you may find useful for product applications.
1. Vernes, S.C. et al. (2007) High-throughput analysis of promoter occupancy reveals direct neural targets of FOXP2, a gene mutated in speech and language disorders.Am J Hum Genet. 81 (6): 1232-50. 2. Vernes, S.C. et al. (2006) Functional genetic analysis of mutations implicated in a human speech and language disorder.Hum Mol Genet. 15 (21): 3154-67.
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