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>   home   >   Products   >   Primary Antibodies   >   Anti-Dynorphin B (aa1-13) Antibody (Serum)   

Anti-Dynorphin B (aa1-13) Antibody (Serum)

Rabbit Anti-Pig Polyclonal Antibody

Product Information
  • Applications Legend:
  • WB=Western Blot
  • IHC=Immunohistochemistry
  • IHC-P=Immunohistochemistry (Paraffin-embedded Sections)
  • IHC-F=Immunohistochemistry (Frozen Sections)
  • IF=Immunofluorescence
  • FC=Flow Cytopmetry
  • IC=Immunochemistry
  • ICC=Immunocytochemistry
  • IP=Immunoprecipitation
  • DB=Dot Blot
  • CHIP=Chromatin Immunoprecipitation
  • FA=Fluorescence Assay
  • IEM=Immunoelectronmicroscopy
  • EIA=Enzyme Immunoassay
Primary Accession P01214
Reactivity Pig
Host Rabbit
Clonality Polyclonal
Isotype Polyclonal IgG
Calculated MW 28617 Da
Additional Information
Other Species B,Chimpanzee,Dog,Gorilla,Hs,H,M,Rh,Ha,Rat,Gp,M
Purification Antisera to Dynorphin B (1-13) were raised by repeated immunisation of rabbits with highly purified antigen.
Immunogen Synthetic peptide, YGGFLRRQFKVVT, corresponding to full-length porcine dynorphin B (1-13), conjugated to thyroglobulin.
Shelf Life 18 months from date of despatch.
Gene ID 445529
Other Names Proenkephalin-B, Beta-neoendorphin-dynorphin, Preprodynorphin, Alpha-neoendorphin, Beta-neoendorphin, Big dynorphin, Big Dyn, Dynorphin A(1-17), Dyn-A17, Dynorphin A, Dynorphin A(1-13), Dynorphin A(1-8), Leu-enkephalin, Rimorphin, Dynorphin B, Dyn-B, Dynorphin B(1-13), Leumorphin, Dynorphin B-29, PDYN
Target/Specificity Rabbit anti-Dynorphin B antibody recognizes dynorphin B, an endogenous opioid peptide, also known as rimorphin with the peptide sequence Tyr-Gly-Gly-Phe-Leu-Arg-Arg-Gln-Phe-Lys-Val-Val-Thr, derived from the sequential cleavage of pro-enkephalin B to form leumorphin which is, in turn cleaved to form dynorphin B (Devi et al. 1985). The cleavage of the dynorphin precursors to form the dynorphin neuropeptides is largely controlled by the serine protease cathepsin L which co-localizes with dynorphins in secretory vesicles of brain cortical neurons(Funkelstein et al. 2010) and prohormone convertase 2, a member of the furin, peptidate S8 family (Schwarzer 2009).Dynorphin b sequence is well conserved among mammal, avian (Youngrenet al.1993) and reptilian (Goldsmithet al. 1992) species. Rabbit anti-Dynorphin b antibody is expected to have a wide species cross reactivity.
Preservative & Stabilisers 0.09% Sodium Azide; 1% Bovine Serum Albumin;
Storage Store at +4℃ or at -20 ℃.
PrecautionsAnti-Dynorphin B (aa1-13) Antibody (Serum) is for research use only and not for use in diagnostic or therapeutic procedures.
Citations (0)

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1. Khachaturinan, H., Lewis, M.E., Haber, S.N., Houghten, R.A., Akil, H. and Watson, S.J. (1985) Pro-Dynorphin peptide immunocytochemistry in rhesus monkey brain.
Peptides 6 (Suppl.2): 155-166. 2. Sherman, T.G. et al. (1988) Regulation of hypothalamic magnocellular neuropeptides and their mRNAs in the Brattleboro rat: coordinate responses to further osmotic challenge
J. Neuroscience 8: 3785 - 3796 3. Neal, C.R. and Newman, S.W. (1989) Prodynorphin Peptide Distribution in the Forebrain of the Syrian Hamster and Rat: A Comparative Study with Antisera Against Dynorphin A, Dynorphin B, and the C-Terminus of the Prodynorphin Precursor Molecule.
J. Comp. Neurology 288: 353-386. 4. Zhang, L. et al. (2004) Cocaine-induced intracellular signaling and gene expression are oppositely regulated by the dopamine D1 and D3 receptors.
J Neurosci. 24: 3344-54. 5. Darmopil, S. et al. (2009) Genetic inactivation of dopamine D1 but not D2 receptors inhibits L-DOPA-induced dyskinesia and histone activation.
Biol Psychiatry. 66: 603-13. 6. Ruiz-DeDiego, I. et al. (2014) Activation of DREAM (Downstream Regulatory Element Antagonistic Modulator), a Calcium-Binding Protein, Reduces L-DOPA-Induced Dyskinesias in Mice.
Biol Psychiatry. pii: S0006-3223(14)00224-8.

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Cat# ABD11288
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