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Anti-Human CD184 / CXCR4 Antibody

Rabbit Anti-Human Polyclonal Antibody

  • ICC - Anti-Human CD184 / CXCR4 Antibody  ABD11311
    Immunocytochemical staining of HeLa cells with Rabbit anti Human CD184 / CXCR4
  • WB - Anti-Human CD184 / CXCR4 Antibody  ABD11311
    Western Blot analysis of HeLa whole cell lysate probed with Rabbit anti Human CD184 / CXCR4
Product Information
  • Applications Legend:
  • WB=Western Blot
  • IHC=Immunohistochemistry
  • IHC-P=Immunohistochemistry (Paraffin-embedded Sections)
  • IHC-F=Immunohistochemistry (Frozen Sections)
  • IF=Immunofluorescence
  • FC=Flow Cytopmetry
  • IC=Immunochemistry
  • ICC=Immunocytochemistry
  • IP=Immunoprecipitation
  • DB=Dot Blot
  • CHIP=Chromatin Immunoprecipitation
  • FA=Fluorescence Assay
  • IEM=Immunoelectronmicroscopy
  • EIA=Enzyme Immunoassay
Primary Accession P61073
Reactivity Human
Host Rabbit
Clonality Polyclonal
Isotype Polyclonal IgG
Calculated MW 39746 Da
Additional Information
Purification Purified IgG prepared by ion exchange chromatography
Immunogen Peptide sequence corresponding to amino acids 1-14 of human CD184 / CXCR4.
Shelf Life 18 months from date of despatch.
Gene ID 7852
Other Names C-X-C chemokine receptor type 4, CXC-R4, CXCR-4, FB22, Fusin, HM89, LCR1, Leukocyte-derived seven transmembrane domain receptor, LESTR, Lipopolysaccharide-associated protein 3, LAP-3, LPS-associated protein 3, NPYRL, Stromal cell-derived factor 1 receptor, SDF-1 receptor, CD184, CXCR4
Target/Specificity Rabbit anti-Human CD184 / CXCR4 antibody recognizes the human G-protein-coupled chemokine receptor CD184, also known as CXCR4. CD184 is a 352 amino acid ~40 kDa cell surface protein known to act as a co-factor in HIV infection of CD4+ T cells (Bleulet al.1997). Mutations in the CD184 gene are associated with WHIM syndrome (WHIMS), an inherited combined immunodeficiency disease (Taniuchiet al..).
Preservative & Stabilisers 0.09% Sodium Azide (NaN3)
Storage Store at +4℃ or at -20 ℃.
PrecautionsAnti-Human CD184 / CXCR4 Antibody is for research use only and not for use in diagnostic or therapeutic procedures.
Research Areas
Citations (0)

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1. Nguyen, D.H. and Taub, D. (2002) CXCR4 function requires membrane cholesterol: implications for HIV infection.
J Immunol. 168: 4121-6. 2. Zaitseva, M. et al. (2005) Increased CXCR4-dependent HIV-1 fusion in activated T cells: role of CD4/CXCR4 association.
J Leukoc Biol. 78: 1306-17. 3. Taniuchi, S. et al. (2005) The role of a mutation of the CXCR4 gene in WHIM syndrome.
Haematologica. 90:1271-1272. 4. Rubie, C. et al. (2008) Differential CXC receptor expression in colorectal carcinomas.
Scand J Immunol. 68: 635-44. 5. Rubie, C. et al. (2006) Chemokine expression in hepatocellular carcinoma versus colorectal liver metastases.
World J Gastroenterol. 12: 6627-33. 6. Oliveira Frick, V. et al. (2011) Changes in CXCL12/CXCR4-chemokine expression during onset of colorectal malignancies.
Tumour Biol. 32: 189-96. 7. Moll, N.M. et al. (2009) Imaging correlates of leukocyte accumulation and CXCR4/CXCL12 in multiple sclerosis.
Arch Neurol. 66: 44-53.

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Cat# ABD11311
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