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>   home   >   Products   >   Primary Antibodies   >   Signal Transduction   >   Anti-Human Cytochrome P450 2C9 Antibody (Serum)   

Anti-Human Cytochrome P450 2C9 Antibody (Serum)

Rabbit Anti-Human Polyclonal Antibody

  • IF - Anti-Human Cytochrome P450 2C9 Antibody (Serum) ABD11377
    Published customer image:Rabbit anti Human cytochrome p450 2C9 antibody used for the detection of P450 2C9 expressing cells in liver sections by immunofluorescence.Image caption:Experimental timeframe and analysis of human hepatocyte engraftment in HUHEP and HIS-HUHEP mice. (A) Time course of the experiment indicating the age of the mice at each step. Human albumin (hAlb) plasma levels were analyzed longitudinally in HUHEP (n = 4) (B) and HIS-HUHEP (n = 5) (C) mice. (D, E, F and G) Immunofluorescence analysis of HUHEP (left) and HIS-HUHEP (right) liver sections for anti-hAlb (red stain) co-stained with either (D) anti-E-Cadherin (green stain), or (E) anti-Occludin (green stain), or (F) anti-human Cyp2C9 (green stain), or (G) anti-human Cyp3A4 (green stain) expression. Nuclei are stained with DAPI (blue). Scale bar represents 100 microm.From: Strick-Marchand H, Dusséaux M, Darche S, Huntington ND, Legrand N, et al. A Novel Mouse Model for Stable Engraftment of a Human Immune System and Human Hepatocytes.PLoS ONE 10: e0119820.
Product Information
  • Applications Legend:
  • WB=Western Blot
  • IHC=Immunohistochemistry
  • IHC-P=Immunohistochemistry (Paraffin-embedded Sections)
  • IHC-F=Immunohistochemistry (Frozen Sections)
  • IF=Immunofluorescence
  • FC=Flow Cytopmetry
  • IC=Immunochemistry
  • ICC=Immunocytochemistry
  • IP=Immunoprecipitation
  • DB=Dot Blot
  • CHIP=Chromatin Immunoprecipitation
  • FA=Fluorescence Assay
  • IEM=Immunoelectronmicroscopy
  • EIA=Enzyme Immunoassay
WB, IHC-F, Func
Primary Accession P11712
Reactivity Human
Host Rabbit
Clonality Polyclonal
Isotype Polyclonal IgG
Calculated MW 55628 Da
Additional Information
Purification Antisera to human CYP2C9 were raised by repeated immunisation of rabbits with highly purified antigen.
Immunogen Purified human CYP2C9 expressed in E.coli.
Shelf Life 18 months from date of despatch.
Gene ID 1559
Other Names Cytochrome P450 2C9, 1.14.13.-, (R)-limonene 6-monooxygenase,, (S)-limonene 6-monooxygenase,, (S)-limonene 7-monooxygenase,, CYPIIC9, Cytochrome P-450MP, Cytochrome P450 MP-4, Cytochrome P450 MP-8, Cytochrome P450 PB-1, S-mephenytoin 4-hydroxylase, CYP2C9, CYP2C10
Target/Specificity Rabbit anti-Human Cytochrome P450 2C9 antibody recognizes human cytochrome p450 2C9 (CYP2C9). P450 enzymes are divided into two groups: steroidogenic and xenobiotic (Hornsbyet al.1989). The latter group is comprised of three families 1, 2 and 3. The xenobiotic p450's are involved in most oxidative drug metabolism (Murrayet al.1992). Work in this area is ongoing but studies suggest that all known drug metabolism is mediated by family members:CYP3A, CYP2D6, CYP1A2, CYP2C9/10, CYP2C19 and CYP2E1.Rabbit anti-human cytochrome P450 2C9 is a neutralizing antibody which is a potent inhibitor of CYP2C9 activity. Inhibition of CYP2C19 activity has also been observed.
Preservative & Stabilisers Preservative Free
Storage Store at -20℃ only.
PrecautionsAnti-Human Cytochrome P450 2C9 Antibody (Serum) is for research use only and not for use in diagnostic or therapeutic procedures.
Research Areas
Citations (0)

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1. Ng, P.S. et al. (2003) Production of inhibitory polyclonal antibodies against cytochrome P450s.
Drug Metab Pharmacokinet. 18 (3): 163-72. 2. Larsen, B.T. et al. (2006) Epoxyeicosatrienoic and dihydroxyeicosatrienoic acids dilate human coronary arterioles via BK(Ca) channels: implications for soluble epoxide hydrolase inhibition.
Am J Physiol Heart Circ Physiol. 290(2): H491-9. 3. Dai, D.P. et al. (2013) In vitro functional characterization of 37 CYP2C9 allelic isoforms found in Chinese Han population.
Acta Pharmacol Sin. 34 (11): 1449-56. 4. Schmelzle, M. et al. (2011) Esophageal cancer proliferation is mediated by cytochrome P450 2C9 (CYP2C9).
Prostaglandins Other Lipid Mediat. 94 (1-2): 25-33. 5. Guo, Y. et al. (2005) Role of CYP2C9 and its variants (CYP2C9*3 and CYP2C9*13) in the metabolism of lornoxicam in humans.
Drug Metab Dispos. 33: 749-53. 6. Dai, D.P. et al. (2014) CYP2C9 polymorphism analysis in Han Chinese populations: building the largest allele frequency database.
Pharmacogenomics J. 14 (1): 85-92. 7. Schmidt, A. et al. (2011) Differential expression of glutamine synthetase and cytochrome P450 isoforms in human hepatoblastoma.
Toxicology. 281: 7-14. 8. Malaplate-Armand, C. et al. (2005) Down-regulation of astroglial CYP2C, glucocorticoid receptor and constitutive androstane receptor genes in response to cocaine in human U373 MG astrocytoma cells.
Toxicol Lett. 159: 203-11. 9. Guo, Y. et al. (2005) Catalytic activities of human cytochrome P450 2C9*1, 2C9*3 and 2C9*13.
Xenobiotica. 35: 853-61.1. Werck-Reichhart, D. and Feyereisen, R. (2000) Protein family review Cytochromes P450: a success story.
Genome Biology. 1: 1-9

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Cat# ABD11377
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