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>   home   >   Products   >   Primary Antibodies   >   Signal Transduction   >   Anti-Human Cytochrome P450 3A4 Antibody (Serum)   

Anti-Human Cytochrome P450 3A4 Antibody (Serum)

Rabbit Anti-Human Polyclonal Antibody

  • WB - Anti-Human Cytochrome P450 3A4 Antibody (Serum) ABD11378
    Published customer image:Rabbit anti Human p450 3A4 antibody used for the detection of p450 3A4 in human neuroblastoma lysates by western blottingImage caption:Expression of CYP1A1, 1B1 and 3A4 in human neuroblastoma cell lines UKF-NB-3, UKF-NB-4 and SK-N-AS by Western blot.From: Hřebačková, J, Poljaková J, Eckschlager T, Hraběta J, Procházka P, Smutný S,Stiborová M. Histone deacetylase inhibitors valproate and trichostatin A aretoxic to neuroblastoma cells and modulate cytochrome P450 1A1, 1B1 and 3A4expression in these cells.Interdiscip Toxicol. 2009 Sep;2:205-10.
  • IF - Anti-Human Cytochrome P450 3A4 Antibody (Serum) ABD11378
    Published customer image:Rabbit anti Human cytochrome p450 3A4 antibody used for the detection of P450 3A4 expressing cells in liver sections by immunofluorescence.Image caption:Experimental timeframe and analysis of human hepatocyte engraftment in HUHEP and HIS-HUHEP mice. (A) Time course of the experiment indicating the age of the mice at each step. Human albumin plasma levels were analyzed longitudinally in HUHEP (n = 4) (B) and HIS-HUHEP (n = 5) (C) mice. (D, E, F and G) Immunofluorescence analysis of HUHEP and HIS-HUHEP liver sections for anti-hAlb (red stain) co-stained with either (D) anti-E-Cadherin (green stain), or (E) anti-Occludin (green stain), or (F) anti-human Cyp2C9 (green stain), or (G) anti-human Cyp3A4 (green stain) expression. Nuclei are stained with DAPI . Scale bar represents 100 microm.From: Strick-Marchand H, Dusséaux M, Darche S, Huntington ND, Legrand N, et al. A Novel Mouse Model for Stable Engraftment of a Human Immune System and Human Hepatocytes.PLoS ONE 10(3): e0119820.
Product Information
  • Applications Legend:
  • WB=Western Blot
  • IHC=Immunohistochemistry
  • IHC-P=Immunohistochemistry (Paraffin-embedded Sections)
  • IHC-F=Immunohistochemistry (Frozen Sections)
  • IF=Immunofluorescence
  • FC=Flow Cytopmetry
  • IC=Immunochemistry
  • ICC=Immunocytochemistry
  • IP=Immunoprecipitation
  • DB=Dot Blot
  • CHIP=Chromatin Immunoprecipitation
  • FA=Fluorescence Assay
  • IEM=Immunoelectronmicroscopy
  • EIA=Enzyme Immunoassay
WB, Func
Primary Accession P08684
Reactivity Human
Host Rabbit
Clonality Polyclonal
Isotype Polyclonal IgG
Calculated MW 57343 Da
Additional Information
Purification Antisera to human CYP3A4 were raised by repeated immunisation of rabbits with highly purified antigen.
Immunogen Purified human CYP3A4 expressed in E.Coli
Shelf Life 18 months from date of despatch.
Gene ID 1576
Other Names Cytochrome P450 3A4, 1.14.13.-, 1, 8-cineole 2-exo-monooxygenase,, Albendazole monooxygenase,, Albendazole sulfoxidase, CYPIIIA3, CYPIIIA4, Cytochrome P450 3A3, Cytochrome P450 HLp, Cytochrome P450 NF-25, Cytochrome P450-PCN1, Nifedipine oxidase, Quinine 3-monooxygenase,, Taurochenodeoxycholate 6-alpha-hydroxylase,, CYP3A4, CYP3A3
Target/Specificity ABD11378 recognises human cytochrome p450 3A4 (CYP3A4). P450 enzymes are divided into two groups: steroidogenic and xenobiotic. The latter group is comprised of three families 1, 2 and 3. The xenobiotic p450's are involved in most oxidative drug metabolism. Work in this area is ongoing but studies suggest that all known drug metabolism is mediated by family members:CYP3A, CYP2D6, CYP1A2, CYP2C9/10, CYP2C19 and CYP2E1. ABD11378 is a neutralizing antibody which is a specific and potent inhibitor of CYP3A4.
Preservative & Stabilisers Preservative Free
Storage Store at -20℃ only.
PrecautionsAnti-Human Cytochrome P450 3A4 Antibody (Serum) is for research use only and not for use in diagnostic or therapeutic procedures.
Research Areas
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1. Vranová, I. et al. (2013) The Anticancer Drug Ellipticine Induces Cytochromes P450 1A1, 1A2 and 3A, Cytochrome b5 and NADPH:Cytochrome P450 Oxidoreductase in Rat Liver, Kidney and Lung
Int. J. Electrochem. Sci., 8 (2013) 1586 - 97 2. Ng, P.S. et al. (2003) Production of inhibitory polyclonal antibodies against cytochrome P450s.
Drug Metab Pharmacokinet. 18 (3): 163-72. 3. Song, Z. et al. (2009) Efficient generation of hepatocyte-like cells from human induced pluripotent stem cells.
Cell Res. 19: 1233-42. 4. Schmidt, A. et al. (2011) Differential expression of glutamine synthetase and cytochrome P450 isoforms in human hepatoblastoma.
Toxicology. 281 (1-3): 7-14. 5. Hřebačková, J. et al. (2009) Histone deacetylase inhibitors valproate and trichostatin A are toxic to neuroblastoma cells and modulate cytochrome P450 1A1, 1B1 and 3A4 expression in these cells.
Interdiscip Toxicol. 2: 205-10. 6. Poljaková, J. et al. (2013) Electrochemical Determination of Enzymes Metabolizing Ellipticine in Thyroid Cancer Cells - a Tool to Explain the Mechanism of Ellipticine Toxicity to these Cells
Int. J. Electrochem. Sci. 8: 1573 - 85 7. Strick-Marchand, H. et al. (2015) A novel mouse model for stable engraftment of a human immune system and human hepatocytes.
PLoS One. 10 (3): e0119820.1. Werck-Reichhart, D. & Feyereisen, R. (2000) Cytochromes P450: a success story.
Genome Biol. 1 (6): REVIEWS3003.

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Cat# ABD11378
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