|Calculated MW||20508 Da|
|Purification||Antisera to human Bmf were raised by repeated immunisations of rabbits with highly purified antigen. Purified IgG was prepared from whole serum by affinity chromatography.|
|Immunogen||Peptide sequence EPSQCVEELEDDV corresponding to amino acids 2-14 of human Bmf.|
|Shelf Life||18 months from date of despatch.|
|Other Names||Bcl-2-modifying factor, BMF|
|Target/Specificity||Rabbit anti-BMF antibody recognizes Bcl-2 modifying factor (Bmf), a pro-apoptotic member of the Bcl-2 protein family. Bmf is constitutively expressed in healthy tissues and is sequestered to myosin V motors by association with the dynein light chain 2. Disruption of the actin cytoskeleton is thought to trigger release and activation of Bmf, initiating apoptotic processes downstream.|
|Preservative & Stabilisers||0.02% Sodium Azide|
|Storage||Store at +4℃ or at -20 ℃.|
|Precautions||Anti-BMF (N-Terminal) Antibody is for research use only and not for use in diagnostic or therapeutic procedures.|
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Provided below are standard protocols that you may find useful for product applications.
1. Puthalakath, H. et al. (2001) Bmf: a pro-apoptotic BH3-only protein regulated by interaction with the myosin V actin motor complex, activated by anoikis. Science. 293: 1829-32.
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