|Application ||WB, IHC-P, E, Func|
|Calculated MW||11389 Da|
|Purification||Antisera to human GRO-beta were raised by repeated immunisations of rabbits with highly purified antigen. Purified IgG prepared by affinity chromatography.|
|Immunogen||Recombinant human GRO-beta.|
|Shelf Life||12 months from date of reconstitution.|
|Other Names||C-X-C motif chemokine 2, Growth-regulated protein beta, Gro-beta, Macrophage inflammatory protein 2-alpha, MIP2-alpha, GRO-beta(5-73), GRO-beta-T, Hematopoietic synergistic factor, HSF, SB-251353, CXCL2, GRO2, GROB, MIP2A, SCYB2|
|Target/Specificity||Rabbit anti-Human GRO beta antibody recognizes human GRO-beta, also known as Growth-regulated protein beta, C-X-C motif chemokine 2, Macrophage inflammatory protein 2-alpha, MIP-2α or CXCL2. GRO beta is a ~7.9 kDa CXC chemokine and one of three closely related, but distinct GRO gene products, which act as chemoattractants and activators of neutrophils and basophils.Like GRO-alpha (CXCL1) and GRO-gamma (CXCL3), GRO-beta contains the ELR-motif (N-terminal Glu-Leu-Arg amino acid sequence) and signals through the CXCR1 and CXCR2 receptors, though studies have shown that GRO-beta has a lower potency and receptor binding affinity (Geiseret al.1993).|
|Preservative & Stabilisers||Preservative Free|
|Storage||Prior to reconstitution store at +4℃. Following reconstitution store at -20℃.|
|Precautions||Anti-Human GRO beta Antibody is for research use only and not for use in diagnostic or therapeutic procedures.|
Thousands of laboratories across the world have published research that depended on the performance of antibodies from Abgent to advance their research. Check out links to articles that cite our products in major peer-reviewed journals, organized by research category.
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Provided below are standard protocols that you may find useful for product applications.
1. Haskill, S. et al. (1990) Identification of three related human GRO genes encoding cytokine functions.Proc Natl Acad Sci U S A. 87 (19): 7732-6. 2. Geiser, T. et al. (1993) The Interleukin-8-related chemotactic cytokines GROalpha, GRObeta, and GROgamma activate human neutrophil and basophil leukocytes. J. Biol. Chem. 268: 15419-15424. 3. Kogan-Sakin, I. et al. (2009) Prostate stromal cells produce CXCL-1, CXCL-2, CXCL-3 and IL-8 in response to epithelia-secreted IL-1.Carcinogenesis 30: 698-705.
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