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>   home   >   Products   >   Primary Antibodies   >   Signal Transduction   >   Anti-Human Indoleamine 2,3-Dioxygenase Antibody    

Anti-Human Indoleamine 2,3-Dioxygenase Antibody

Sheep Anti-Human Polyclonal Antibody

Product Information
  • Applications Legend:
  • WB=Western Blot
  • IHC=Immunohistochemistry
  • IHC-P=Immunohistochemistry (Paraffin-embedded Sections)
  • IHC-F=Immunohistochemistry (Frozen Sections)
  • IF=Immunofluorescence
  • FC=Flow Cytopmetry
  • IC=Immunochemistry
  • ICC=Immunocytochemistry
  • IP=Immunoprecipitation
  • DB=Dot Blot
  • CHIP=Chromatin Immunoprecipitation
  • FA=Fluorescence Assay
  • IEM=Immunoelectronmicroscopy
  • EIA=Enzyme Immunoassay
Primary Accession P14902
Reactivity Human
Host Sheep
Clonality Polyclonal
Isotype Polyclonal IgG
Calculated MW 45326 Da
Additional Information
Other Species Marmoset,Rh
Purification Antisera to human indoleamine dioxygenase (IDO) were raised by repeated immunisation of sheep with highly purified antigen. Ig fraction prepared by ammonium sulphate precipitation.
Immunogen Recombinant human indoleamine 2,3-dioxygenase.
Shelf Life 18 months from date of despatch.
Gene ID 3620
Other Names Indoleamine 2, 3-dioxygenase 1, IDO-1,, Indoleamine-pyrrole 2, 3-dioxygenase, IDO1, IDO, INDO
Target/Specificity Sheep anti-Human Indoleamine 2,3-Dioxygenase antibody recognises human indoleamine 2,3-dioxygenase (IDO), an enzyme that is responsible for converting tryptophan to kynurenines. IDO is expressed by a wide variety of tissues and IDO can be upregulated by interferon gamma. IDO modulates levels of the amino acid tryptophan, which is vital for cell growth, but is also involved in the suppression of the immune response. Reports suggest that IDO is involved in the suppression of the immune response to tumours and blocking the IDO pathway may be a potential target for immunotherapy.
Preservative & Stabilisers 0.09% Sodium Azide
Storage Store at +4℃ or at -20 ℃.
PrecautionsAnti-Human Indoleamine 2,3-Dioxygenase Antibody is for research use only and not for use in diagnostic or therapeutic procedures.
Research Areas
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1. Genescà, M. et al. (2012) Live-attenuated lentivirus immunization modulates innate immunity and inflammation while protecting rhesus macaques from vaginal simian immunodeficiency virus challenge.
J Virol. 86 (17): 9188-200. 2. Drenzek, J.G. et al. (2008) Expression of indoleamine 2,3-dioxygenase in the rhesus monkey and common marmoset.
J Reprod Immunol. 78 (2): 125-33. 3. von Bergwelt-Baildon, M.S. et al. (2006) CD25 and indoleamine 2,3-dioxygenase are up-regulated by prostaglandin E2 and expressed by tumor-associated dendritic cells in vivo: additional mechanisms of T-cell inhibition.
Blood. 108: 228-37. 4. Scheler, M. et al. (2007) Indoleamine 2,3-dioxygenase (IDO): the antagonist of type I interferon-driven skin inflammation?
Am J Pathol. 171: 1936-43. 5. Popov, A. et al. (2006) Indoleamine 2,3-dioxygenase-expressing dendritic cells form suppurative granulomas following Listeria monocytogenesinfection.
J Clin Invest. 116: 3160-70. 6. Torres, M.I. et al. (2007) Tryptophan metabolism and indoleamine 2,3-dioxygenase expression in coeliac disease.
Clin Exp Immunol. 148: 419-24. 7. Popov, A. et al. (2008) Infection of myeloid dendritic cells with Listeria monocytogenes leads to the suppression of T cell function by multiple inhibitory mechanisms.
J Immunol. 181: 4976-88. 8. von Bubnoff, D. et al. (2012) Indoleamine 2,3-dioxygenase expression in early keratocyte neoplasia of the lower lip correlates to the degree of cell atypia.
Pathol Int. 62: 105-11. 9. von Bubnoff, D. et al. (2011) Indoleamine 2,3-dioxygenase-expressing myeloid dendritic cells and macrophages in infectious and noninfectious cutaneous granulomas.
J Am Acad Dermatol. 65 (4): 819-32.1. Munn, D.H. & Mellor, A.L. (2004) IDO and tolerance to tumors.
Trends Mol Med. 10 (1): 15-8.

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Cat# ABD11435
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