|Application ||WB, IHC-P|
|Calculated MW||45326 Da|
|Purification||Antisera to human indoleamine dioxygenase (IDO) were raised by repeated immunisation of sheep with highly purified antigen. Ig fraction prepared by ammonium sulphate precipitation.|
|Immunogen||Recombinant human indoleamine 2,3-dioxygenase.|
|Shelf Life||18 months from date of despatch.|
|Other Names||Indoleamine 2, 3-dioxygenase 1, IDO-1, 126.96.36.199, Indoleamine-pyrrole 2, 3-dioxygenase, IDO1, IDO, INDO|
|Target/Specificity||Sheep anti-Human Indoleamine 2,3-Dioxygenase antibody recognises human indoleamine 2,3-dioxygenase (IDO), an enzyme that is responsible for converting tryptophan to kynurenines. IDO is expressed by a wide variety of tissues and IDO can be upregulated by interferon gamma. IDO modulates levels of the amino acid tryptophan, which is vital for cell growth, but is also involved in the suppression of the immune response. Reports suggest that IDO is involved in the suppression of the immune response to tumours and blocking the IDO pathway may be a potential target for immunotherapy.|
|Preservative & Stabilisers||0.09% Sodium Azide|
|Storage||Store at +4℃ or at -20 ℃.|
|Precautions||Anti-Human Indoleamine 2,3-Dioxygenase Antibody is for research use only and not for use in diagnostic or therapeutic procedures.|
Thousands of laboratories across the world have published research that depended on the performance of antibodies from Abgent to advance their research. Check out links to articles that cite our products in major peer-reviewed journals, organized by research category.
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Provided below are standard protocols that you may find useful for product applications.
1. Genescà, M. et al. (2012) Live-attenuated lentivirus immunization modulates innate immunity and inflammation while protecting rhesus macaques from vaginal simian immunodeficiency virus challenge.J Virol. 86 (17): 9188-200. 2. Drenzek, J.G. et al. (2008) Expression of indoleamine 2,3-dioxygenase in the rhesus monkey and common marmoset.J Reprod Immunol. 78 (2): 125-33. 3. von Bergwelt-Baildon, M.S. et al. (2006) CD25 and indoleamine 2,3-dioxygenase are up-regulated by prostaglandin E2 and expressed by tumor-associated dendritic cells in vivo: additional mechanisms of T-cell inhibition.Blood. 108: 228-37. 4. Scheler, M. et al. (2007) Indoleamine 2,3-dioxygenase (IDO): the antagonist of type I interferon-driven skin inflammation?Am J Pathol. 171: 1936-43. 5. Popov, A. et al. (2006) Indoleamine 2,3-dioxygenase-expressing dendritic cells form suppurative granulomas following Listeria monocytogenesinfection.J Clin Invest. 116: 3160-70. 6. Torres, M.I. et al. (2007) Tryptophan metabolism and indoleamine 2,3-dioxygenase expression in coeliac disease.Clin Exp Immunol. 148: 419-24. 7. Popov, A. et al. (2008) Infection of myeloid dendritic cells with Listeria monocytogenes leads to the suppression of T cell function by multiple inhibitory mechanisms.J Immunol. 181: 4976-88. 8. von Bubnoff, D. et al. (2012) Indoleamine 2,3-dioxygenase expression in early keratocyte neoplasia of the lower lip correlates to the degree of cell atypia.Pathol Int. 62: 105-11. 9. von Bubnoff, D. et al. (2011) Indoleamine 2,3-dioxygenase-expressing myeloid dendritic cells and macrophages in infectious and noninfectious cutaneous granulomas.J Am Acad Dermatol. 65 (4): 819-32.1. Munn, D.H. & Mellor, A.L. (2004) IDO and tolerance to tumors.Trends Mol Med. 10 (1): 15-8.
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