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Anti-Human FEN1 Antibody

Rabbit Anti-Human Polyclonal Antibody

  • WB - Anti-Human FEN1 Antibody  ABD11437
    Detection of human Fen1 in whole cell lysates of HeLa and 293T cells (5-50 mcg/lane) by Western blotting with Rabbit anti Human Fen1 . Immunoprecipitation was with AHP837 (3mcg/mg lysate) or another anti Fen1 polyclonal antibody, subsequent detection of immunoprecipitated Fen1 by Western blotting used Rabbit anti Fen-1 antibody
Product Information
  • Applications Legend:
  • WB=Western Blot
  • IHC=Immunohistochemistry
  • IHC-P=Immunohistochemistry (Paraffin-embedded Sections)
  • IHC-F=Immunohistochemistry (Frozen Sections)
  • IF=Immunofluorescence
  • FC=Flow Cytopmetry
  • IC=Immunochemistry
  • ICC=Immunocytochemistry
  • IP=Immunoprecipitation
  • DB=Dot Blot
  • CHIP=Chromatin Immunoprecipitation
  • FA=Fluorescence Assay
  • IEM=Immunoelectronmicroscopy
  • EIA=Enzyme Immunoassay
Primary Accession P39748
Reactivity Human
Host Rabbit
Clonality Polyclonal
Isotype Polyclonal IgG
Calculated MW 42593 Da
Additional Information
Other Species M
Purification Antisera to human FEN1 were raised by repeated immunisation of rabbits with highly purified antigen. Purified IgG prepared by affinity chromatography.
Immunogen Synthetic peptide corresponding to a region within the N terminal domain of human FEN1 (locus link ID 2237)
Shelf Life 12 months from date of reconstitution.
Gene ID 2237
Other Names Flap endonuclease 1 {ECO:0000255|HAMAP-Rule:MF_03140}, FEN-1 {ECO:0000255|HAMAP-Rule:MF_03140}, 3.1.-.- {ECO:0000255|HAMAP-Rule:MF_03140}, DNase IV, Flap structure-specific endonuclease 1 {ECO:0000255|HAMAP-Rule:MF_03140}, Maturation factor 1, MF1, hFEN-1, FEN1 {ECO:0000255|HAMAP-Rule:MF_03140}, RAD2
Target/Specificity Rabbit anti-Human FEN1 antibody recognizes human Flap endonuclease 1 also known as Flap structure-specific endonuclease, FEN1, Maturation factor 1 or DNase IV. FEN1 is a 380 amino acid ~45kDa member of the FEN1 sub family of XPG/RAD2 endonucleases which has an important role in lagging strand DNA synthesis and base excision repair (Kimet al.1998). It is hypothesised that FEN1 may play a role in the inhibltion of triplet repeat expansion (Vallur and Maizels 2010).Two isoforms of FEN1 are generated by alternative initiation, isoform 1 against which rabbit anti-human FEN1 antibody is generated and a truncated isoform FENMIT, lacking the N-terminal region and having a mitochondrial distribution, FENMIT also lacks DNAase activity (Kazaket al.2013). Initial results suggest that rabbit anti-human FEN1 antibody does not recognize the truncated form of human FEN1.Fen1 is expressed in the nucleus of a wide variety of organ strusctures notably in those of the hematopoietic system including spleen, lymph nodes and spleen. Rabbit anti-human FEN1 antibody recognizes a band of ~45kDa in whole cell lysates of HeLa and 293T by western blotting and has successfully been used for immunoprecipitation of FEN1 from HeLa cell lysates.
Preservative & Stabilisers 0.09% Sodium Azide (NaN3)
Storage Store at +4℃. DO NOT FREEZE.
PrecautionsAnti-Human FEN1 Antibody is for research use only and not for use in diagnostic or therapeutic procedures.
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Cat# ABD11437
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