|Calculated MW||101579 Da|
|Purification||Antisera to phosphorylated GluR1 were raised by repeated immunisations of rabbits with highly purified antigen. Purified IgG was prepared by sequential affinity chromatography on phospho- and dephosphopeptide affinity columns.|
|Immunogen||Synthetic phosphopeptide corresponding to amino acid sequence within GluR1 which includes the phosphorylated residue Ser831.|
|Shelf Life||12 months from date of reconstitution.|
|Other Names||Glutamate receptor 1, GluR-1, AMPA-selective glutamate receptor 1, GluR-A, GluR-K1, Glutamate receptor ionotropic, AMPA 1, GluA1, Gria1, Glur1|
|Target/Specificity||Rabbit anti-phosphorylated GluR1 antibody recognizes rat glutamate receptor subunit 1 (GluR1) when phosphorylated at serine 831.GluR1, widely expressed throughout the nervous system is a component of AMPA receptors (alpha-amino-3-hydroxy-5-methyl-4-isoxalone propionic acid receptors), which play a key role at excitatory synapses.Phosphorylation of Ser831 and Ser845 is reported to potentiate GluR1 function, suggesting a possible role in synaptic plasticity, learning and memory.|
|Preservative & Stabilisers||0.09% Sodium Azide; 0.01% Bovine Serum Albumin; 50% Glycerol|
|Storage||Store at +4℃ or at -20 ℃.|
|Precautions||Anti-GluR1 (pSer831) Antibody is for research use only and not for use in diagnostic or therapeutic procedures.|
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Provided below are standard protocols that you may find useful for product applications.
1. Castellani, G.C. et al. (2001) A biophysical model of bidirectional synaptic plasticity: Dependence on AMPA and NMDA receptors.Proc. Natl. Acad. Sci. USA. 98: 12772 - 12777.
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