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Anti-4EBP1 (C-Terminal) Antibody

Rabbit Anti-Human Polyclonal Antibody

  • ICC - Anti-4EBP1 (C-Terminal) Antibody  ABD11522
    Immunocytochemical stainig of 3T3 cells with Rabbit anti Human 4E-BP1
  • WB - Anti-4EBP1 (C-Terminal) Antibody  ABD11522
    Western blot analysis of whole cell lysates from 3t3 mouse embryonic fibroblast cells probed with Rabbit anti Human 4E-BP1 at 2.5(A), 5(B) and 10(C) ug/ml
Product Information
  • Applications Legend:
  • WB=Western Blot
  • IHC=Immunohistochemistry
  • IHC-P=Immunohistochemistry (Paraffin-embedded Sections)
  • IHC-F=Immunohistochemistry (Frozen Sections)
  • IF=Immunofluorescence
  • FC=Flow Cytopmetry
  • IC=Immunochemistry
  • ICC=Immunocytochemistry
  • IP=Immunoprecipitation
  • DB=Dot Blot
  • CHIP=Chromatin Immunoprecipitation
  • FA=Fluorescence Assay
  • IEM=Immunoelectronmicroscopy
  • EIA=Enzyme Immunoassay
Primary Accession Q13541
Reactivity Human
Host Rabbit
Clonality Polyclonal
Isotype Polyclonal IgG
Calculated MW 12580 Da
Additional Information
Other Species M
Purification Purified IgG prepared by affinity chromatography.
Immunogen A 14 amino acid peptide located near human 4EBP1 carboxy-terminus.
Shelf Life 18 months from date of despatch.
Gene ID 1978
Other Names Eukaryotic translation initiation factor 4E-binding protein 1, 4E-BP1, eIF4E-binding protein 1, Phosphorylated heat- and acid-stable protein regulated by insulin 1, PHAS-I, EIF4EBP1
Target/Specificity ABD11522 recognises an epitope within the C-terminal region (CT) of eukaryotic translation initiation factor 4E binding protein 1 (4EBP1), a rapamycin-sensitive downstream target of TOR (Target of rapamycin), and regulatory factor of eukaryotic mRNA translation. The association between 4EPB1 and eukaryotic translation initiation factor 4E (eIF-4E) inhibits the binding of eIF-4E with p220, thereby preventing the formation of a functional eIF-4E complex, essential for mRNA translation. Phosphorylation of 4EBP1 following stimulation by mitogens such as insulin, results in the release of eIF-4E from 4EBP1, thereby enabling the translation complex to assemble. ABD11522 has been reported as suitable for use in IHC on mouse 3T3 cell cytospins.
Preservative & Stabilisers 0.02% Sodium Azide (NaN3)
Storage Store at +4℃ or at -20 ℃.
PrecautionsAnti-4EBP1 (C-Terminal) Antibody is for research use only and not for use in diagnostic or therapeutic procedures.
Research Areas
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1. Hara, K. et al (1997) Regulation of eIF-4E BP1 phosphorylation by mTOR*.
J. Biol. Chem. 272: 26457-26463.2. Haghighat, A. et al. (1995) Repression of cap-dependent translation by 4E-binding protein 1: competition with p220 for binding to eukaryotic initiation factor-4E.
EMBO J. 14: 5701-5709

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Cat# ABD11522
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