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Anti-Human Mcl-1 Antibody

Rabbit Anti-Human Polyclonal Antibody

  • WB - Anti-Human Mcl-1 Antibody  ABD11524
    Western blot analysis of whole cell lysate from Raji, Burkitt's lymphoma derived B-lymphoblastoid cells probed with Rabbit anti Human Mcl-1 at 0.5(A), 1(B) and 2(C) ug/ml
  • ICC - Anti-Human Mcl-1 Antibody  ABD11524
    Immunocytochemical staining of Raji cells with Rabbit anti Human Mcl-1
Product Information
  • Applications Legend:
  • WB=Western Blot
  • IHC=Immunohistochemistry
  • IHC-P=Immunohistochemistry (Paraffin-embedded Sections)
  • IHC-F=Immunohistochemistry (Frozen Sections)
  • IF=Immunofluorescence
  • FC=Flow Cytopmetry
  • IC=Immunochemistry
  • ICC=Immunocytochemistry
  • IP=Immunoprecipitation
  • DB=Dot Blot
  • CHIP=Chromatin Immunoprecipitation
  • FA=Fluorescence Assay
  • IEM=Immunoelectronmicroscopy
  • EIA=Enzyme Immunoassay
Primary Accession Q07820
Reactivity Human
Host Rabbit
Clonality Polyclonal
Isotype Polyclonal IgG
Calculated MW 37337 Da
Additional Information
Purification Antisera to human MCL-1 (IN) were raised by repeated immunisations of rabbits with highly purified antigen. Purified IgG prepared by ion exchange chromatography.
Immunogen A 16 amino acid peptide located near the centre of human MCL-1.
Shelf Life 18 months from date of despatch.
Gene ID 4170
Other Names Induced myeloid leukemia cell differentiation protein Mcl-1, Bcl-2-like protein 3, Bcl2-L-3, Bcl-2-related protein EAT/mcl1, mcl1/EAT, MCL1, BCL2L3
Target/Specificity ABD11524 recognises an epitope within the central region (IN) of human Myeloid cell leukaemia sequence 1 (MCL-1), an anti-apoptotic member of the Bcl-2 family of proteins, first identified in differentiating ML-1 myeloid cells, and expressed in many different cell lines, tissues and a variety of tumours.The MCL-1 protein, localised to intracellular membranes and particularly mitochondrial membranes, has since been isolated in two distinct isoforms, known as MCL-1 long (MCL-1L) and MCL-1 short (MCL-1S). MCL-1S has been identified as a pro-apoptotic splice variant of MCL-1L, missing the transmembrane and BH1 and BH2 (Bcl-2 homology) domains. Interaction between these two antagonistic variants can act to regulate cell survival.ABD11524 recognises both the MCL-1L (38kDa) and MCL-1S (30kDa) isoforms of MCL-1.
Preservative & Stabilisers 0.02% Sodium Azide
Storage Store at +4℃ or at -20 ℃.
PrecautionsAnti-Human Mcl-1 Antibody is for research use only and not for use in diagnostic or therapeutic procedures.
Research Areas
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1. Kozopas, K.M. et al. (1993) MCL1, a gene expressed in programmed myeloid cell differentiation, has sequence similarity to BCL2.
P.N.A.S USA 90: 3516-3520.2. Bae, J. et al. (2000) MCL-1S, a splicing variant of the antiapoptotic BCL-2 family member MCL-1, encodes a proapoptotic protein possessing only the BH3 domain.
J. Biol. Chem. 275: 25255-25261.3. Rinkenberger, J.L. et al. (2000) Mcl-1 deficiency results in peri-implantation embryonic lethality.
Genes and Dev. 14: 23-27.

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Cat# ABD11524
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